肝动脉化疗栓塞对肝癌肿瘤新生血管生成的影响  

The Effect of Transcatheter Arterial Chemoembolizationon Angiogenesis in Hepatocellular Carcinoma

作　　者：徐辉[1] 王滨[1] 高志芹[2] 于德新[1] 曹贵文[1] 孙业全[1] 

机构地区：[1]潍坊医学院附属医院影像中心,山东潍坊261031 [2]潍坊医学院细胞生物学教研室

出　　处：《实用放射学杂志》2004年第7期620-622,共3页Journal of Practical Radiology

基　　金：山东省教育厅资助课题 (编号J99K58);山东省科学技术委员会攻关项目资助课题 (项目编号 1 998BB1CCA1 )部分内容

摘　　要：目的　研究肝细胞癌 (hepatocellularcarcinoma ,HCC)经导管动脉化疗栓塞 (transcatheterarterialchemoembolization ,TACE)后残癌组织微血管密度 (microvesseldensity ,MVD)、微血管直径的情况及其意义。方法　经病理证实的HCC 63例 ,包括单纯手术切除42例 (对照组 ) ,TACE术后行Ⅱ期手术切除 2 1例 (TACE组 ) ,TACE组患者手术前接受 1～ 2次不等的TACE术治疗 ,均按统一规范标准给予化疗药物灌注 +栓塞治疗。对手术切除标本进行免疫组化染色 ,其中TACE组取病灶边缘残存肿瘤部分 ,检测肿瘤组织的MVD、微血管直径。结果　对照组MVD值为 5 1.69± 18.17,TACE组MVD值为 5 8.5 7± 15 .75 ,二者之间比较无显著性差异 (t=1.48,P >0 .0 5 ) ;对照组微血管直径为 ( 17.62± 10 .5 4) μm ,TACE组微血管直径为 ( 15 .79± 7.65 ) μm ,二者之间比较无显著性差异 (t =0 .71,P >0 .0 5 )。结论　TACE术很难彻底消除肿瘤血供 。Objective To investigate intratumor microvessel density (MVD) in residual cancerous tissue of hepatocellular carcinoma(HCC) after transcatheter arterial chemoembolization (TACE). Methods Sixty-three cases with HCC verified by histopathology were studied, which included 42 cases treated with surgical resection alone (control group), and 21 cases were underwent TACE prior toⅡ-phase surgical resection (TACE group).TACE included perfusion of chemotherapeutic agents and embolization.The pathological specimens were dealed with immunohistochemical technique. MVD and the diameter of microvessel in tumor tissue were measured respectively. Results The MVD was 51.69±18.17 in the control group and 58.57±15.75 in the TACE group. There was no significant difference between the two groups (t=1.48, P>0.05). The diameter of microvessel was (17.62±10.54)μm in the control group and (15.79±7.65)μm in the TACE group. There was no significant difference between the two groups (t=0.71, P>0.05).Conclusion TACE can not thoroughly eliminate the angiogenesis of the tumor, residual cancerous tissue can gained blood supply again by variant way.

关 键 词：肝动脉化疗栓塞 肝癌 肿瘤新生血管生成 微血管密度 微血管直径 

分 类 号：R735.7[医药卫生—肿瘤]