二氧化碳气腹对肿瘤细胞生长和播散影响的研究  

Study on Influence of Carbon Dioxide Pneumoperitoneum on Growth and Spread of Tumor Cell

作　　者：吴步初[1] 喇端端[1] 季晓琼[1] 沈立翡[1] 龙雯晴[1] 沈育红[1] 邱蔚华[2] 谢弘[3] 

机构地区：[1]上海第二医科大学附属瑞金医院妇产科,上海200025 [2]上海第二医科大学附属瑞金医院普外科,上海200025 [3]中科院上海细胞生物学研究所,上海200031

出　　处：《现代诊断与治疗》2004年第4期199-201,205,共4页Modern Diagnosis and Treatment

基　　金：上海市科技发展基金资助项目 (99B1 2 )

摘　　要：目的　研究静脉使用 5 %NaHCO3 纠正CO2 气腹造成的酸中毒能否改善其对肿瘤细胞的促生长和播散作用。方法　观察静脉推注 5 %NaHCO3 的CO2 气腹组、CO2 气腹组及对照组带瘤Wister大鼠的肿瘤生长及穿刺点转移情况。结果　静脉推注 5 %NaHCO3 的CO2 气腹组、CO2 气腹组及对照组肿瘤的重量、体积和腹水体积有差异 ,但无统计学意义。穿刺点转移率无明显差异。结论　CO2 气腹影响肿瘤细胞生长和播散的机制复杂 ,不能完全以CO2 引起机体酸中毒解释。未找到通过静脉推注 5 %NaHCO3 可改善CO2 气腹对肿瘤细胞生长影响的基础理论依据。Objective To determine if the use of 5% NaHCO 3,which can redress the acidosis caused by CO 2 pneumoperitoneum,could improve its function on the growth and spread of tumor cell.Method Tumor growth and port sites metastasis among group of CO 2 pneumoperitoneum with 5% NaHCO 3 iv,group CO 2 pneumorperitoneum and control group in a murine model were observed.Results The tumor growth was different in the group of CO 2 pneumoperitoneum with 5% NaHCO 3 iv,group CO 2 pneumoperitoneum and control group,but the results had no statistic significances.There was no significant difference in metastasis rate of port sites.Conclusions The mechanism of the effect of CO 2 pneumoperitoneum on tumor growth and spread is complicated,the acidosis of peritoneum and the whole body could not explain it completely.There is no theoretic evidence that the use of 5% NaHCO 3 iv could improve the effect of CO 2 pneumoperitoneum on tumor growth.

关 键 词：二氧化碳气腹 肿瘤细胞 碳酸氢钠 肿瘤转移 肿瘤扩散 NAHCO3 酸中毒 腹腔镜手术 

分 类 号：R73-37[医药卫生—肿瘤]