非小细胞肺癌TGF-β1、TRFⅡ及Smad2的表达及其临床病理学意义  

The expression and clinical significance of transforming growth factor beta Ⅰ, TRF Ⅱ and Smad 2 in non-small cell lung carcinoma

作　　者：程慧敏[1] 贾晓民[1] 王鹏程[1] 夏平[1] 戴秀梅[1] 陈超峰[1] 陈卫花[1] 

机构地区：[1]徐州医学院第二附属医院病理科,江苏徐州221006

出　　处：《徐州医学院学报》2004年第4期334-338,共5页Acta Academiae Medicinae Xuzhou

基　　金：江苏省教育厅高等院校自然科学基金课题 (0 2KJD32 0 0 2 8)

摘　　要：目的　探讨转化生长因子 - β1(TGF - β1)、转化生长因子受体Ⅱ (TRFⅡ )及Smad蛋白 2 (Smad 2 )在非小细胞肺癌中的表达特征与临床病理学因素的关系。方法　应用免疫组织化学技术分析 5 6例非小细胞肺癌手术切除标本中TGF - β1、TRFⅡ及Smad 2的分布特征 ,并分析不同临床病理学因素下的表达特征。结果　非小细胞肺癌TGF - β1、TRFⅡ及Smad 2的表达与肺癌的TNM分期、组织类型、淋巴管侵袭、淋巴结转移、肿瘤区微血管数量、肿瘤区微血管类型、肿瘤间质反应、神经纤维周围间隙侵袭有关 ,而与年龄、性别、肿瘤最大直径、淋巴组织反应、远处转移等无关。结论　非小细胞肺癌TGF - β1、TRFⅡ及Smad 2的表达与临床病理学因素的分析对于判断其局部生物学行为、复发及预后具有重要意义。Objective To investigate the expression and clinical significance of transforming growth factor beta Ⅰ,TRF Ⅱ and Smad 2 in human non-small cell lung carcinoma (NSCLC).Methods The clinicopathologic factors were analyzed in the pneumonectomy specimens from 56 cases of lung carcinoma by pathologic, immunohistochemical and histochemical methods.Results The expression of TGF-β1, TRF Ⅱ and Smad 2 in NSCLC was mainly associated with TNM stage,histologic classification, lymphatic invasion, lymph node involvement, type and degree of microvascularity in tumor tissue, interstitial reaction and perineurofibrous invasion, but was not with age, sex, tumor size, lymphatic tissues reaction or distant metastasis.Conclusion Analysis of TGF-β1, TRF Ⅱ, Smad 2 and clinicopathologic factors be of significant value in judging the biological behaviors, recurrence and prognosis of non-small cell lung carcinoma.

关 键 词：非小细胞肺癌 TGF-Β1 转化生长因子-β1 TRFⅡ 转化生长因子受体Ⅱ Smad蛋白2 生物学行为 临床病理学 基因表达 

分 类 号：R734.2[医药卫生—肿瘤]