31例腹膜后恶性纤维组织细胞瘤的诊疗经验  

Malignant fibrous histocytoma of the retroperitoneum: an analysis of 31 cases

作　　者：王宝贵[1] 梁寒[1] 崔青皓[1] 王家仓[1] 柳建中[1] 

机构地区：[1]天津医科大学附属肿瘤医院腹部肿瘤科,300060

出　　处：《中华肿瘤杂志》2004年第6期373-374,共2页Chinese Journal of Oncology

摘　　要：目的　探讨腹膜后恶性纤维组织细胞瘤 (MFH)的诊疗方法。方法　回顾性分析 31例腹膜后MFH的临床病理特点、治疗方法及其预后。结果　 31例患者男性 2 2例 ,女性 9例 ,平均年龄(5 2 .7± 14 .1)岁。主要临床表现为腹部肿块和腹痛 ,肿瘤平均直径为 (14 .9± 6 .6 )cm。组织学类型以炎症型 (16例 )和车辐状多形型 (10例 )多见。术后 1,3,5年生存率为 6 1.3%± 9.8% ,31.6 %± 11.3%和 2 1.1%± 11.4 % ,中位生存期为 (17.0± 6 .3)个月。手术切除的彻底性是影响术后生存期的主要因素。结论　腹膜后MFH治疗应以手术彻底切除为主 ,联合术后放化疗 。Objective To investigate the diagnosis and treatment of malignant fibrous histiocytoma of the retroperitoneum(MFHR). Methods The clinicopathological features, treatment and prognosis of 31 patients with MFHR were retrospectively analyzed. Results The mean age of the patients was 52.7±14.1 years. Male:Female = 22∶9. The primary symptoms were abdominal mass and pain. The average diameter of tumor was 15 cm . The histopathologic types of the tumor were inflammatory, storiform pleomorphic, myxoid and giant cell in 16, 10, 4 and 1 cases. The overall survival rate of 1 , 3 and 5 year was 61.3%±9.8%, 31.6%±11.3% and 21.1%± 11.4% with a median survival time of 17.0±6.3 months. Complete resection of the tumor was the major prognostic factor. Postoperative radiotherapy of 20 45 Gy was able to prolong the median survival from 12.1± 11.6 months of surgery alone to 26.4±22.0 months of surgery plus postoperative radiotherapy though without statistical significance( P =0.051). Postoperative CHOP chemotherapy was not shown to be beneficial. ConclusionChemotherapy remains the important method of cure. The survival in patients with MFHR might be improved by complete resection combined with chemotherapy or/and radiotherapy.

关 键 词：腹膜 恶性纤维组织细胞瘤 MFH 肿瘤 治疗方法 

分 类 号：R735.4[医药卫生—肿瘤]