帕金森病患者脑多巴胺转运体SPECT功能显像研究进展  

Imaging of dopamine transporter with single photon emission computed tomography in patients with Parkinson disease

作　　者：苏敬敬[1] 谢惠君[1] 

机构地区：[1]第二军医大学长海医院神经内科,上海200433

出　　处：《第二军医大学学报》2004年第7期785-787,共3页Academic Journal of Second Military Medical University

基　　金：国家科技攻关资助项目 ( 2 0 0 1BA70 2 B0 2 )

摘　　要：单光子发射计算机断层显像 (single photon emission computed tom ography,SPECT)利用特异放射性核素与人脑多巴胺神经元突触前膜脑多巴胺转运体 (DAT)的高度亲和性 ,可进行帕金森病 (PD)患者脑 DAT显像 ,目前已广泛应用于 PD患者的临床实践。大量研究表明 ,SPECT对于 PD患者的早期诊断、鉴别诊断、病情监测、疗效评价及预后具有重要意义。本文对 PD患者脑 DATSingle photon emission computed tomography(SPECT)can be used in Parkinson desease due to the high affinity of the specific isotope with dopamine transporter(DAT).Nowadays,SPECT imaging in human brain is widely applied in clinical practice of Parkinson disease,such as early diagnosis,differential diagnosis,monitoring,outcome evaluation and prognosis.In this article,a survey is conducted on DAT SPECT imaging and its clinical application in patients with Parkinson disease.

关 键 词：多巴胺转运体 单光子发射计算机断层显像 帕金森病 

分 类 号：R742.5[医药卫生—神经病学与精神病学]