直线加速器联合骨膦治疗恶性肿瘤骨转移疗效观察  

THE TREATMENT OF MALIGNANT TUMOR BONE METASTASIS BY LINEAR ACCELERATOR AND BONEFOS:A Therapeutic-effect Observation

作　　者：穆立祥[1] 党文生[1] 闫留玉[1] 

机构地区：[1]河南科技大学第一附属医院,洛阳471003

出　　处：《中医正骨》2004年第6期10-11,共2页The Journal of Traditional Chinese Orthopedics and Traumatology

摘　　要：为评价直线加速联合骨膦治疗恶性肿瘤骨转移的疗效。将50例恶性肿瘤骨转移伴骨痛患者随机分为治疗组和对照组,治疗组用直线加速联合骨膦治疗,对照组单用骨膦治疗。结果显示治疗组和对照组疼痛完全缓解率分别为76%和44%(0.01<P<0.05);平均止痛起效时间分别为5±2 .1d和7±2.8d(P<0.01);平均止痛持续时间分别为120±14d和68±20d(P<0.01);Karnofsky评分提高10分以上的例数分别为占52%和40%(P>0.05),表明直线加速联合骨膦治疗恶性肿瘤骨转移止痛效果好,起效快,作用时间持久,并且可治疗高血钙症,预防病理性骨折。In order to evaluate the therapeutic effect of linear accelerator and bonefos on malignant-tumor bone metastasis, 50 cases of malignant-tumor bone metastasis with bone pains were divided into the treated and control groups, which were treated by linear accelerator and bonefos and by bonefos alone, respectively. The results showed that the treated and control groups had 76 % and 44 % of complete-pain-relief rates (0.01 < P < 0.05), 5±2.1 d and 7±2.8 d of mean initial-pain-relief time (P < 0.01), 120±14 d and 68±20 d of mean-durative-analgesic time (P > 0.01) and 52 % and 40 % of the cases with an increase of over 10 points according to the Karnofsky's scoring (P > 0.05), respectively, suggesting that linear accelerator and bonefos could produce a good analgesia, early initial-relief-pain and long durative-relief-pain time in the treatment of malignant-tumor bone metastasis. This method can also be used to treat hypercalcemia and to prevent pathological fracture.

关 键 词：肿瘤 骨转移/治疗 放射治疗 骨膦 临床研究 

分 类 号：R730.5[医药卫生—肿瘤]