还原型辅酶Ⅰ对抗肿瘤药物抑制人胃癌细胞的影响  

Impact of Reduced CoenzymeⅠon Inhibition of Human Gastric Cancer Cells by Antitumor Drugs

作　　者：喻卫红 潘铁[2] 李晓霞[2] 

机构地区：[1]辽宁省肿瘤研究所,辽宁沈阳110042 [2]辽宁省肿瘤医院,辽宁沈阳110042

出　　处：《中国肿瘤》2004年第7期443-445,共3页China Cancer

摘　　要：[目的]研究还原型辅酶Ⅰ(NADH)对抗肿瘤药物抑制人胃癌SGC鄄7901细胞活性的影响。[方法]用MTT法观察NADH和抗肿瘤药物氟尿嘧啶、鬼臼乙叉甙、顺铂、表阿霉素、丝裂霉素对人胃癌SGC鄄7901细胞活性的抑制率。[结果]NADH可明显降低氟尿嘧啶、鬼臼乙叉甙、顺铂、表阿霉素的肿瘤细胞抑制率(P<0.05)。并且可显著提高人胃癌细胞对丝裂霉素的化疗敏感性(P<0.01)。[结论]NADH可能是肿瘤化疗过程中的重要调节剂。To investigate the impact of reduced coenzyme Ⅰ(NADH) on inhibition of human gastric cancer cells by antitumor drugs.The inhibition rate of tumor cells with NADH and antitumor drugs of 5-Fu,Vp-16, DDP, EPI and MMC were observed by MTT assay.NADH markedly decreased the inhibition rate of 5-Fu,Vp-16, DDP,and EPI on tumor cells (P<0.05)and significantly increased the sensitivity of human gastric cancer cells to MMC(P<0.01).[Conclusions]NADH may be an important adjuster for chemotherapy.

关 键 词：还原型辅酶Ⅰ(NADH) 抗肿瘤药物 肿瘤细胞抑制率 血浆高峰浓度 

分 类 号：R73-3[医药卫生—肿瘤]