非清髓性外周血干细胞移植治疗慢性粒细胞白血病  

NONMYELOABLATIVEPERI PHERAL BLOOD PROGENITOR TRANSPLANTATION FOR REFRACTORY LEUKEMIA

作　　者：丁家华[1] 陈宝安[1] 董伟民[1] 王骏[1] 赵刚[1] 高冲[1] 孙耘玉[1] 金宝翠[1] 程坚[1] 

机构地区：[1]东南大学附属中大医院血液科,江苏南京210009

出　　处：《白血病．淋巴瘤》2004年第3期136-138,共3页Journal of Leukemia & Lymphoma

摘　　要：目的：观察非清髓造血干细胞移植对慢粒慢性期(CML-CP)、慢粒加速期(CML-AP)的疗效。方法：用福达华(F)30mg／m^2×6d，白消安(B)4mg·kg^-1·d^-1×2d，环磷酰胺(CTX)600mg／d×2d，±Ara-C对7例HLA全相合者进行预处理，并对其造血恢复等指标动态观察。结果：7例患者造血顺利恢复．ANC>0．5×10VL平均为13d，BPC>20×10^9／L平均为11d。+30天时经短串重复系列(STR-PCR)检测，7例植活患者中4例为完全嵌舍状态(CDC)，3例为混合嵌合体。+90天时又有1例患者转为CDC。中位随访6(1-13)个月，7例患者均无病生存。结论：非清髓性造血干细胞移植是慢粒慢性期、加速期的有效治疗手段，对于年龄较大患者亦有良好耐受性。Objective:Tostudytheeffectofnonmyeloablativeperipheralbloodprogenitortransplanta-tioninchronicmyelogenousleukemiainchronicpharse(CML蛳CP)、acceleratedpharse(CML蛳AP).Methods:Weapproachednonmyeloablativeperipheralbloodprogenitortransplantationin7patientswithHLA蛳A,B,DRmatchedsiblingsdonors.Theconditioningregimensincludedfludarabine30mg/m2×6d,busulphan4mg·kg-1·d-1×2d,CTX600mg/d×2d,±Ara蛳C.Results:7patientswereallsuccessfullyengrafted.Themediantimesfortheirneutrophilreturningto≥0.5×109/Landforplateletreturningto≥20×109/Lwere13daysand11daysrespectively.On+30d,chimaerismusingpolymerasechainreaction(PCR)蛳basedassaysanalyzingpolymorphicshorttandemrepeat(STR)markersshowed4patientsreachedcompletedonorchimerism(CDC),3patientsreachedmixedchimerism.on+90d,oneofthese3finallyreachedCDC.All7patientswerealiveanddisease蛳freewithamedianfollow蛳uptimeof6(1~13)months.Conclusion:Non-myeloablativeperipheralbloodprogenitortransplantationiseffectiveinthetreatmentofCML蛳CP、CML蛳AP,andissuitableforoldpatients.

关 键 词：造血干细胞移植 异基因 非清髓 白血病 慢粒 

分 类 号：R733.72[医药卫生—肿瘤]