重性抑郁障碍与心境恶劣障碍患者若干临床问题的比较研究  

Comparative study on some clinical problems between patients with major depressive disorder and with dysthymic disorder

作　　者：林涛[1] 蔡焯基[1] 杨蕴萍[1] 王丽颖[1] 

机构地区：[1]首都医科大学附属北京安定医院心理科,北京市100088

出　　处：《中国临床康复》2004年第21期4179-4181,共3页Chinese Journal of Clinical Rehabilitation

基　　金：首都医学发展科研基金资助项目(首都ZD199816)~~

摘　　要：目的:比较重性抑郁障碍(majordepressivedisorder,MDD)与心境恶劣障碍(dysthymicdisorder,DD)患者的一般人口学资料、神经内分泌、生活变动事件、人格及抗抑郁剂的疗效。方法:根据美国精神障碍诊断与统计手册第4版(DSM-Ⅳ)共完成38例患者(MDD组20例,DD组18例)的比较。采用分析性病例对照研究对两组入组前一般人口学资料、生活事件量表(LES)、个性诊断问卷(PDQ-4+)、血浆三碘甲状腺原氨酸(T3)、甲状腺素(T4),地塞米松抑制试验(DST)进行比较,采用同期对照实验对噻奈普汀治疗8周后的疗效进行比较。结果:①MDD首发年龄犤(30.00±11.63)岁犦晚于DD犤(22.89±7.43)岁犦,差异有显著性意义(t=2.268,P<0.05);其他一般人口学资料以及LES,PDQ-4+,T3,T4,DST两组比较,差异无显著性(P>0.05)。②根据HAMD减分率,MDD组和DD组的有效率(80%和72%)、显效率(50%和28%)、痊愈率(15%和6%)两组比较差异无显著性(P>0.05)。结论:MDD与DD在若干临床问题方面基本一致,推测两者可能是同一疾病。AIM:To compare several clinical problems between major depressive disorder(MDD) and dysthymic disorder(DD). METHODS:Comparison was conducted between MDD group(n=20) and DD group(n=18) according to the Diagnostic and Statistical Manual of Mental Disorders(DSM Ⅳ).General demographic data,life event scale(LES),personality diagnostic questionnaire(PDQ 4?),triiodothyronine (T3),tetraiodothyronine(T4) and dexamethasone suppression test(DST) were compared before the patients were admitted into this study by using case control study,and the curative effects were compared 8 weeks after the treatment of tianeptine.a$RESULTS:￠ùThe age of the first episode of MDDComparative study on some clinical problems between patients with major depressive disorder and with dysthymic disordeCONCLUSION:MDD and DD are very similar in some clinical aspects with each other,so it is assumed that they may be the same disease.

关 键 词：重性抑郁障碍 心境恶劣障碍 人格 抗抑郁剂 神经内分泌学 生活变动事件 

分 类 号：R749.4[医药卫生—神经病学与精神病学]