针灸抗突变效应的实验研究  

Studies of the Effect of Anti-mutation with Acupunctur and Moxibustion

作　　者：张世敏[1] 魏会平[1] 杨春玫[1] 田翠时[1] 李继红[1] 

机构地区：[1]河北北方学院,河北张家口075029

出　　处：《癌变．畸变．突变》2004年第4期239-241,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：背景与目的 :以小鼠骨髓嗜多染红细胞微核率及染色体畸变率的变化 ,研究针灸的抗突变作用。 材料与方法 :以小鼠为实验动物 ,以环磷酰胺为诱变剂 ,分正常对照组 ,阳性对照组 ,针灸预防Ⅰ、Ⅱ组 ,针灸治疗Ⅰ、Ⅱ组 ,针刺实验组小鼠足三里、艾灸关元穴 ,检测小鼠骨髓嗜多染红细胞微核率及染色体畸变率的变化。 结果 :阳性对照组与正常对照组比较骨髓嗜多染红细胞微核率及染色体畸变率升高 ,预防各组和治疗各组低于阳性对照组。 结论 :针灸可以拮抗由环磷酰胺诱导的小鼠骨髓嗜多染红细胞微核率及染色体畸变率的升高 。BACKGROUND&AIM: To study the effect of anti_mutation by testing bone marrow cells micronucleus and chromosome aberration with Acupunctur and Moxibustion. MATERIAL AND METHODS: 96mice were divided6groups:1,normal control group;2,positive control group;3,prevention groupⅠ;4,prevention groupⅡ;5,treatment groupⅠ;6,treatment groupⅡ.In the2～6groups,all the mice were treated with ip.CP.50mg/kg body weight,and in the3～6groups,the mice were acupuncted the acupuncture points of Zusanli,moxaed the acupuncture points of Guanyuan.At the end of experiment,all the mice were decapitated,tested bone marrow cells micronucleus and chromosome aberration. RESULTS: Compared with1group,in2group,the bone marrow cells micronucleus and chroˉmosome aberration were significantly highter.Compared with2group,in3～6groups,these indexes were signifiˉcantly lower(P<0.01). Conclusion: Acupuncting the acupuncture points of Zusanli and moxaing the acupuncture points of Guanyuan can prevent or treat the bone marrow cells micronucleus and chromosome aberration of mouse,which increased by CP.

关 键 词：针灸 抗突变 微核 染色体畸变 

分 类 号：R994[医药卫生—毒理学]