PTEN、Survivin在食管癌发生发展中的作用  

The Roles of PTEN and Survivin in Carcinogenesis and Development of Esophageal Carcinoma

作　　者：任秀花[1] 张孝艳[2] 阎爱华[1] 常福聚[1] 

机构地区：[1]郑州大学基础医学院癌前期研究室,河南郑州450052 [2]河南大学医学院病理教研室,河南开封475001

出　　处：《河南肿瘤学杂志》2004年第4期238-240,共3页Henan Journal of Oncology

摘　　要：目的　检测PTEN、Survivin蛋白在食管正常黏膜、单纯增生、不典型增生、原位癌及浸润癌中的表达情况 ,分析这两种蛋白在食管癌不同病变区域中的表达及与食管癌病理特征的关系。方法　采用免疫组化方法检测PTEN、Survivin蛋白在 60例食管癌大体标本中的不同病变区域的表达。结果　PTEN蛋白从正常黏膜→单纯增生→不典型增生→原位癌→浸润癌呈渐进性低表达 ,而Sur vivin蛋白则呈渐进性高表达。PTEN、Survivin蛋白在正常黏膜与浸润癌中的表达有显著性差异 (P <0 .0 1) ;PTEN蛋白表达与淋巴结转移有关 (P <0 .0 5 )。PTEN蛋白在食管浸润癌中的低表达与Survivin蛋白在其中的高表达呈负相关 (r =-0 3 90 ,P <0 .0 1)。结论PTEN、Survivin二种基因与食管癌的发生发展密切相关 。Objective To detect the expressions of PTEN and Survivin in different epithelial lesions, including normal, hyperplasia, displasia, carcinoma in situs and invasive carcinoma and to analyze the expressions of PTEN and Survivin correlated with pathologic characteristics. Methods Immunohistochemistry was used to detect the expressions of PTEN and Survivin in 60 cases of whole specimen of esophageal carcinoma with different degree epithelial lesions. Results The expressions of Survivin were progressively increasing and those of PTEN were reducing in the course from normal to invasive carcinoma. Significant difference was observed in the expressions of PTEN and Survivin between normal mucosa and carcinoma in situs, invasive carcinoma( P <0.01). The expressions of PTEN showed signifcant correlation with lymph node metastasis ( P <0.05). There was a trend for an inverse relationship between PTEN expression and Survivin expression(r=-0 390, P <0.01). Conclusion The expressions of PTEN and Survivin were significantly related to the occurrence and progression of esophageal carcinoma. They may be the important markers for tumor diagnosis.

关 键 词：食管癌 免疫组化 PTEN SURVIVIN 

分 类 号：R735.1[医药卫生—肿瘤]