Tourette综合征亚型听觉事件相关电位显著性概率地形图分析  

Significance probability mapping analysis for auditory event-related potentials on Tourette syndrome

作　　者：吴大兴[1] 朱焱 姚树桥[1] 苏林雁 王湘[1] 

机构地区：[1]中南大学湘雅二院医学心理研究中心,湖南省长沙市410011 [2]精神卫生研究所儿童精神医学教研室,湖南省长沙市410011

出　　处：《中国临床康复》2004年第22期4454-4456,共3页Chinese Journal of Clinical Rehabilitation

基　　金：国家自然科学青年基金资助项目(30100054)~~

摘　　要：目的:探讨伴与不伴注意缺陷多动障碍(attentiondeficiencyandhyperac-tivitydisorder,ADHD)的Tourette综合征亚型听觉事件相关电位(event-relatedpotentials,ERPs)的颅脑电位分布特征。方法:应用显著性概率地形图方法对19例Tourette综合征单纯组、15例Tourette综合征伴有ADHD组和20例正常对照组的听觉ERPs结果进行对比分析。结果:Tourette综合征伴有ADHD组与正常组相比,N1,N2波在左中央区、左顶颞区差异有显著性意义(t=2.02～3.68,P<0.05)。Tourette综合征单纯组与正常组相比,只有P3a波在前额区、左右中央区、左右枕颞区差异有显著性意义(t=2.24～3.08,P<0.05)。而Tourette综合征伴有ADHD组与单纯组相比,则是P3a波在左顶颞区差异有显著性意义(t=2.12～2.95,P<0.05)。结论:伴与不伴ADHD的Tourette综合征亚型之间大脑认知功能损害发生阶段不同,可能存在一定的生物异质性。AIM:To investigate the character of cerebral region relevant to auditory event -related potentials(ERPs) of Tourette's syndrome(TS) with and without attention deficiency and hyperactivity Disorder(ADHD). METHODS:The auditory ERPs results of 19 TS,15 TS with ADHD and 20 normal contr ols were analyzed with significance probability mapping(SPM). RESULTS:There were significant differences in left occipital, parietal,and tem poral scalp regions for N1 and N2 between TS with ADHD group and normal control group(t=2.02-3.68,P< 0.05).Only prefrontal,left and right occipital, left and r ight parietal-temporal scalp regions for P3a between TS group and normal contro l group had significant differences(t=2.24-3.08,P< 0.05),but left parietal-tem poral scalp regions for P3a between TS with ADHD and TS groups had significant d ifferences(t=2.12-2.95,P< 0.05). CONCLUSION:Some biological different characters may exist at the different sta ges of cerebral cognition function damage between TS with and without ADHD.

关 键 词：TOURETTE综合征 诊断 注意缺陷多动障碍 事件相关电位 听觉 脑图 

分 类 号：R748[医药卫生—神经病学与精神病学]