脑出血患者预后与血脂血糖及凝血等指标变化的相关性  

Correlation of prognosis with the changes of blood glucose and blood lipid and blood coagulation in patients with cerebral hemorrhage

作　　者：陈渝宁[1] 孙蕾[1] 郑锦辉 郑威[1] 

机构地区：[1]解放军沈阳军区总医院检验科,110015 [2]解放军第二二医院检验科,辽宁省沈阳市100003

出　　处：《中国临床康复》2004年第22期4512-4513,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:检测脑出血时多种指标的变化,探讨对脑出血患者预后的影响。方法:测定50例脑出血患者的凝血、纤溶指标,血糖、血脂水平,白细胞含量及血小板和相关指标的改变。结果:脑出血组血糖、三酰甘油、载脂蛋白B、低密度脂蛋白胆固醇水平显著高于对照组(P<0.05),血清低密度脂蛋白胆固醇水平低于正常值(P<0.05)。脑出血组D二聚体含量为(2.35±1.70)mg/L,大于对照组(0.31±0.25)mg/L,差异有显著性意义(P<0.05),而凝血指标与对照组差异无显著性意义。脑出血组白细胞含量显著增加,血小板及相关指标未受影响。急性期血糖增高者较血糖正常组预后差,病死率高。结论:血脂异常与脑出血的发生关系密切,脑出血对血糖水平、白细胞数量及纤溶状态均有一定程度的影响,但对血小板和相关指标影响不大。提示急性期血糖增高预示预后不良。AIM:To study the changes of many indexes in patients with cerebral hemorrhage, in order to determine the prognosis of the patients. MOTHODS:The values of blood coagulation and fibrinolysis in 50 patients with c erebral hemorrhage were assayed.At the same time,blood glucose, blood lipid,whit e blood cells(WBCs)and blood platelet were examined. RESULTS:Compared with the control group,the blood glucose,triacylglycerol(TG), apolipoprotein B(ApoB)and low density lipoprotein-cholesterol (LDL-C)in the ce rebral hemorrhage group were significantly higher(P< 0.05),while serum LDL-C le vel was lower than the normal value(P< 0.05).The D-dimer (DD) contents in the c erebral hemorrhage group was (2.35±1.70) mg/L, higher than that in the contr ol group(P< 0.05),and the value of blood coagulation was not markedly different from that in the control group.The level of WBC in the cerebral hemorrhage group was evidently increased,while blood platelet and related indexes had no changes .There were poorer prognosis and higher death rate in those with increased blood glucose during the acute period compared with the normal controls. CONCLUSION:Abnormal blood lipid is closely related with the occurrence of cere bral hemorrhage.The value of blood glucose,number of WBC and fibrinolysis can be affected by cerebral hemorrhage to certain degree,while blood platelet and rela ted indexes are not changed significantly,indicating that the increased blood gl ucose in the acute period can lead to poor prognosis.

关 键 词：脑出血 液 血糖 白细胞 血小板 

分 类 号：R743[医药卫生—神经病学与精神病学]