龟羚帕安丸对血管性帕金森综合征患者运动功能的影响(英文)  

Effect of guiling pa'an wan on motor function in patients with vascular Parkin sonism

作　　者：李彦杰[1] 任德启[1] 

机构地区：[1]河南省中医院内二科,河南省郑州市450002

出　　处：《中国临床康复》2004年第22期4656-4658,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:血管性帕金森综合征(vascularparkinsonism,VP)中医谓之“老年颤证”,应用中医药方法改善患者运动功能的研究报道较少。目的:观察龟羚帕安丸改善血管性帕金森综合征患者运动功能的疗效。设计:以诊断为依据的病例对照研究。地点、对象和干预:1997-07/2003-07河南省中医院收治的VP患者90例,均经CT或MRI证实,未服美多巴制剂,经患者知情同意后随机分为治疗组和对照组。两组均用脉络宁注射液30mL加入250mL/L葡萄糖注射液或生理盐水250mL中静滴,1次/d。治疗组口服龟羚帕安丸,6g/次,3次/d。对照组不用口服药。1个月为1个疗程。两组降压药、降糖药、抗血小板聚集药继续用。主要观察指标:统一帕金森病功能评定量表(Ⅲ)运动检查部分(UPDRSⅢ)评分。结果:两组UPDRSⅢ评分:犤治疗组:治疗前(47.65±4.26)分,治疗后(25.22±3.85)分;对照组:治疗前(46.31±3.98)分,治疗后(34.63±3.65)分犦。治疗组UPDRS评分减少明显优于对照组(t=-11.079,P<0.01)。两组组内治疗前后比较有极显著差异(t=28.428,12.978,P<0.01)。综合疗效治疗组总改善率83%,明显高于对照组总改善率58%(P<0.01)。结论:龟羚帕安丸可明显改善VP患者运动功能。BACKGROUND:Vascular Parkinsonism(VP)is called “senile tremor' in Chinese medi cine,but there is fewer reports concerning the research of Chinese medicine on i mprovement of motor function in VP patients. OBJECTIVE:To observe the therapeutic effects of guiling pa'an wan on improveme nt of motor function in VP patients. DESIGN:Controlled trial study based on diagnosis. SETTING,SUBJECTS and INTERVENTION:Ninety VP patients were collected in Henan H ospital of traditional Chinese Medicine from July 1997 to July 2003,which never took Madopar preparation,verified by CT or MRI.They were divided at random(by lo t-casting method)into treatment group and control group after permission.In bot h groups, mai luo ning zhu she ye(the injection for tranquilizing meridians)30 m L mixed with glucose injection 250 mL/L or physiological saline 250 mL was appli ed for intravenous drip,once per day.In treatment group,guiling pa'an wan was pr ovided,6 g each time and 3 times per day.In the control,there was no any oral-t aken medicine.One month made a course.In both groups,the medicines for lowing bl ood pressure,lowing blood sugar and antiplatelet agglutination were taken contin uously. MAIN OUTCOME MEASURES:Standard Function evaluation table for Parkinsonism(III) and scores of partial motor examination (UPDRS III). RESULTS:Scores of UPDRS III in two groups:[treatment group: before treatment(4 7.65±4.26)scores,after treatment(25.22±3.85)scores;control group:before trea tment(46.31±3.98)scores,after treatment(34.63±3.65)scores].In treatment gro up, the decreasing amplitude of UPDRS score decrease was remarkably more than th at in the control(t=-11.079,P< 0.01).There was more significant difference in t he comparison before and after treatment in each group itself(t= 28.428,12.978, P< 0.01).The total improving rate of comprehensive therapeutic effects in treatm ent group was 83%,which was remarkably higher than the total improving rate of 58% in the control(P< 0.01). CONCLUSION:Guiling pa'an wan remarkably improves motor

关 键 词：帕金森病 症状性 药物疗法 丸剂 龟羚帕安丸 血管性帕金森综合征 

分 类 号：R742.5[医药卫生—神经病学与精神病学]