平肝通络颗粒对家兔脑膜血管的双相调节作用(英文)  

Dual-adjusting effect of the ping gan tong luo granules on the small vessels of meninges in rabbits

作　　者：杨维华[1] 孙兆泉[1] 周慎[1] 

机构地区：[1]湖南省中医药研究院内科,湖南省长沙市410006

出　　处：《中国临床康复》2004年第22期4662-4663,共2页Chinese Journal of Clinical Rehabilitation

基　　金：湖南省卫生厅中医药科研基金(98009)~~

摘　　要：背景:药物治疗是偏头痛的主要治疗方法,而对平肝通络中药治疗偏头痛的作用机制的研究较少。目的:证实平肝通络颗粒对家兔脑膜血管具有双相调节作用。设计:完全随机安慰剂及阳性药物对照,单盲实验研究。地点和对象:实验在湖南省中医药研究院动物室完成。采用家兔脑膜血管。市售家兔24只,雌雄不限,体质量2.5～3kg,由湖南省中医药研究院动物室饲养2周以上。干预:平肝通络颗粒十二指肠给药与静脉注射给药的颅通定对照,试验完成、血管管径恢复后,各再给药1次,30min后由耳缘静脉按5μg/kg注射5-羟色胺。主要观察指标:兔脑膜小血管管径值。结果:平肝通络颗粒能够扩张正常家兔脑膜小血管管径,同时明显对抗注射5-羟色胺后兔脑膜血管管径的扩张,呈现双相调节作用。结论:平肝通络颗粒治疗偏头痛有一定的药理学依据。BACKGROUND:Pharmacotherapy is the main treatment for migraine.However,few rese arches have been reported on the mechanism of treating migraine with traditional Chinese medicine ping gan ton gluo. OBJECTIVE:To confirm the dual-adjusting effect of the ping gan tong luo granu les(PGTLG) on the meningeal small vessels in rabbits. DESIGN:A completely randomized,placebo-controlled,and single-blind experimen tal study was conducted. SETTING and PARTICIPANTS:The experiment was completed in the Laboratory Animal Room,Hunan Academy of Traditional Chinese Medicine.Rabbit meningeal vessels wer e used.Twenty-four rabbits,weighing 2.5 to 3 kg were purchased from markets wit h either gender, and kept for more than 2 weeks in the above research room. INTERVENTIONS:PGTLG was given to the duodenum,and intravenously administered t etrahydropalmatine was adopted as control.After the experiments were finished,PG TLG or control was given once more to restore vessel diameters;Thirty minutes la ter,5 μg/kg of 5-HT was injected to the ear vein. MAIN OUTCOME MEASURES:Diameters of meningeal small vessels in rabbits. RESULTS:PGTLG dilated the meningeal small vessels in normal rabbits,and restra ined the dilating of 5-TH-induced meningeal small vessels. CONCLUSION:PGTLG has a promising pharmacological effect in treating migraine.

关 键 词：兔 脑膜 血管 双相调节作用 中药疗法 

分 类 号：R74[医药卫生—神经病学与精神病学]