胶原基纳米骨修复兔下颌骨缺损的实验研究  

Experimental research of mineralized collagen based composite in repairing mandibular defects in rabbits

作　　者：张丽军[1] 王影[2] 吴燕丽[1] 齐小良[1] 张洁[1] 韩志峰[1] 朱菲[1] 姚丽[1] 胡雪兰[1] 崔福斋[3] 

机构地区：[1]北京市和平里医院口腔科,100013 [2]河北医科大学基础医学院病理教研室 [3]清华大学材料科学与工程系

出　　处：《中国骨质疏松杂志》2004年第2期155-157,共3页Chinese Journal of Osteoporosis

基　　金：首都医学发展科研基金资助项目(首都TS199811)

摘　　要：目的 研究胶原基纳米骨(nHAC)修复下颌骨缺损的效果,以期为临床提供一种理想的骨替代材料。方法 在32只成年兔双侧下颌骨形成0.8 mm×0.6mm全层骨膜骨质缺损,每一缺损作为一个实验单位。术后4、5、6、8、10、11、12周取材,行大体标本、X线片、组织学和扫描电镜观察。结果 nHAC与CPC相比同期成骨量大。8周时nHAC成骨情况尚不如Bio-Oss。而12周时已接近Bio-Oss成骨水平。空白缺损则未能修复。结论 nHAC生物相容性好,效果较好于CPC,远期与Bio-Oss相似,是一种较为理想的骨替代材料。Objective To study the effects of mineralized collagen based composite (nHAC) in repairing mandibular defects in rabbits, in order to provide an ideal bone replacement material for clinic. Methods 8 mm × 6 mm bilateral mandibular periosteum bone defects were made surgically in 32 Japan adult rabbits. The defects were randomly repaired with nHAC. Bio-Oss and CPC at 4、5、6、8、10、11、12 weeks after surgery, blank control group was stayed. Speciments obtained were evaluated with general observation, X-ray , histological microscopic and semanalysis. Results New bone formed and calcified earlier in nHAC and the bone area was greater in the same period than that in CPC. The new bone area in nHAC was still smaller than of Bio-Oss at 8 weeks, while at 12 weeks they had no significant differences. The blank defects were not repaired even in the end. Conclusion nHAC had sound biocompatibility. It was better than CPC and can be compared with Bio-Oss 12 weeks after opera-tion. So it can be an ideal alternative for bone replacement.

关 键 词：胶原基纳米骨 修复 兔 下颌骨缺损 实验 骨替代材料 

分 类 号：R782.23[医药卫生—口腔医学] R318.17[医药卫生—临床医学]