新型1,2,4-三唑并[3,2-d][1,5]苯并氧氮杂-2-酮的合成  

Synthesis of Novel 1,2,4-Triazolo[3,2-d][1,5]benzoxazepin-2-ones

作　　者：李诤[1] 王全瑞[1] 陶凤岗[1] 

机构地区：[1]复旦大学化学系,上海200433

出　　处：《有机化学》2004年第8期893-897,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金 (No.2 0 372 0 1 5)资助项目

摘　　要：取代苯并二氢吡喃 4 酮 ( 1)的芳腙在冰醋酸中与KNCO发生 [3 +2 ]环加成反应 ,加成产物经KMnO4氧化开环得偕偶氮异氰酸酯 ( 3 ) .3在HBF4的催化下发生环化 -重排反应 ,合成得到一系列新型 6 7 5三环系 1,2 ,4 三唑并 [3 ,2 d] [1,5 ]苯并氧氮杂 2 酮 ( 5a～ 5g) .由X单晶衍射测定了化合物A series of novel tricyclic O,N-heterocycles 5a～5g, a kind of unprecedented 1,2,4-triazolo[3,2-d]~[1,5]benzoxazepin-2-ones, have been achieved via acid-induced ring closure of isocyanatoarylazo compounds 3, which were prepared from chroman-4-one in three steps, followed by feasible rearrangement. The structural assignment of 5a has been ultimately accomplished by X-ray diffraction analysis.

关 键 词：1 2 4-三唑并[3 2-d][1 5]苯并氧氮杂zhuǒ-2-酮 合成 偕偶氮异氰酸酯 关环 重排 神经系统药物 

分 类 号：TQ25[化学工程—有机化工]