荧光素衍生物抗癌活性的模式识别  

Pattern Recognition for the Antitumour Activity of Some Fluorescein Derivatives

作　　者：李丙瑞[1] 何凤英[1] 王流芳[1] 

机构地区：[1]兰州大学化学系,兰州730000

出　　处：《高等学校化学学报》1993年第7期954-956,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：近年来,我们以荧光素为母体合成了一系列的衍生物,药理试验证实其中许多种对肿瘤细胞有明显的杀伤和抑制增殖作用。本文用非线性映照(NLM)模式识别技术研究其活性分类,得到分类清晰的映照图,确定了该类衍生物抗ECa 109细胞的主要结构因素,为指导合成新化合物建立了预报模型。 1In this paper, some antitumour fluorescein derivatives were classified according to their activity using Non-Linear Mapping (NLM) pattern recognition techniques. Three sets of structural parameters, {ΣMR, F2, (Σ)2}, {ΣMR, F2, π3} and {ΣMR, ΣF, (Σπ)2} were screened out. The results showed that the main structural factors influencing the antitumour activity of these substances are their molar refraction, hydrophobicity and field inductive effect, especially field inductive effect of 2-substituent, whereas conjugative effect is not. The forecast model about antitumour activity of the derivatives were established and further syntheses were suggested by this research.

关 键 词：模式识别 荧光素衍生物 抗癌活性 

分 类 号：R96[医药卫生—药理学]