钙纳米粒子的制备及表征鉴定  

Preparation and Identification of Calcium Nanoparticles

作　　者：郑金榆[1] 蔡振[2] 戚晓红[3] 李玉华[1] 李芸茜[1] 王祝鸣[3] 冯振卿[1] 

机构地区：[1]南京医科大学病理学与病理生理学系,江苏南京210029 [2]南京医科大学化学系,江苏南京210029 [3]南京医科大学生物纳米技术研究中心,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2004年第4期335-336,354,共3页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金资助项目(30170836);政府"863"计划资助项目(2002AA214181)

摘　　要：目的:制备钙纳米粒子并进行表征鉴定。方法:采用液相沉淀法,在不同温度、缓冲液、液体混合方式下制备钙纳米粒子,并用透射电镜(TEM)、粒度分布仪、X射线能谱仪(XPS)等测试手段对该纳米粒子的结构、大小和形状等进行表征。结果:低温下向柠檬酸钠中匀速缓慢加入等量氯化钙和磷酸氢二钠并搅拌,可得到颗粒状钙纳米粒子,平均粒径260 nm,XPS结果显示其化学成分为磷酸钙。结论:通过液相沉淀法,成功制备了大小、形态较理想的钙纳米粒子。To prepare and identify Ca nanoparitcles. Methods: The Ca nanoparitcles were prepared by precipitation method at different temperatures, buffers or mixing orders. The structure, particle size and morphology of resulting nanoiparticles were characterized by transmission electron microscope (TEM) , particle meter and X-ray photoelectron spectrometer (XPS). Results: It was indicated that granular nanoparticles average diameter 260 nm could be prepared by adding calcium chloride and dibasic sodium phosphate slowly into sodium citrate at low temperature with stirring. The component of nanoparticles was calcium phosphate proved by XPS. Conclusion: The resulting Ca nanoparticles were obtained by precipitation methods.

关 键 词：沉淀法 制备 钙纳米粒子 微结构 

分 类 号：R364.5[医药卫生—病理学] Q74[医药卫生—基础医学]