射频肝肿瘤灭活对兔肾功能的影响  

Influence on Kidney in the Treatment of VX_2 Liver Tumor with Radiofrequency Ablation in Rabbits

作　　者：褚朝顺[1] 苗毅[1] 郭峰[1] 奚春华[1] 黄承荣[2] 

机构地区：[1]南京医科大学第一附属医院普外科,江苏南京210029 [2]扬子石化医院检验科,江苏南京210048

出　　处：《南京医科大学学报（自然科学版）》2004年第4期358-360,F003,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省卫生厅重点项目(H200210)

摘　　要：目的:探讨射频肝肿瘤灭活术对肾脏的影响。方法:22只植有VX2肝肿瘤的新西兰白种兔随机分为2组:A组(治疗组n=15),开腹后对肝肿瘤进行射频治疗,功率为30 w,持续3-4 min。B组(对照组n=7),开腹后关腹,不作任何治疗。分别于术前、术后3、7、14天观察血中尿素氮(BUN)、肌酐(Cr)、尿中红细胞和病理变化。结果:A组术后3天尿素氮升高,肌酐升高,尿中红细胞增多,肾小管上皮发生颗粒样变性。术后7天肌酐恢复正常水平,14天后各项指标均恢复正常。B组无明显变化。结论:射频肝肿瘤灭活术对肾脏有影响作用,但是为可逆性暂时性的损害。To study influence on kidney in the treatment of VX2 liver tumor with RFA in rabbits. Methods: Twenty-two New Zealand rabbits bearing a localized VX2 liver tumor were randomly divided into 2 groups. Group A ( n = 15) was treated with RFA by using a cooled-tip technique. The energy output was 3Owatts × (3 -4) min. Group B( n = 7) received sham operation. Kidney injury was observed by examining urea nitrogen (BUN), creatinine(Cr) in blood, urine erytrocytes and renal histology prior to and after RFA. Results: In group A, BUN and Cr in blood and erytrocytes in urine increased remarkably and granular degeneration was found in epithelium of convoluted tubules on the third day after RFA. The Cr levers in blood recovered on the seventh day. All value of determination turned into normal levers on the fourteenth day. In group B, there was no enhanced blood BUN, Cr, urine erytrocytes and renal damage. Conclusion: RFA may result in kidney injury temporarily. It could be a safe therapy for liver tumor.

关 键 词：VX2 肝肿瘤 射频治疗 肾脏 

分 类 号：R735.7[医药卫生—肿瘤]