脑栓塞病人体外模拟血栓试验血液流变学与D-二聚体的相关性初探  

The Primary Study on Relationship Between Hemorrheological-thrombosis in Vitro and the Prima Level of D-dimer of the Patients with Cerebral Embolism

作　　者：罗国辉[1] 罗乐宣 曾莲意[3] 李涛[1] 邝碧娟[1] 张银辉[1] 张允奇[1] 

机构地区：[1]广东医学院深圳心肾疾病研究所,广东深圳518033 [2]深圳市福田区卫生局 [3]深圳市福田区人民医院内科三病区,广东深圳518033

出　　处：《现代检验医学杂志》2004年第4期18-19,共2页Journal of Modern Laboratory Medicine

摘　　要：目的　探讨不同脑栓塞病人的血液流变学、体外模拟血栓形成和 D-二聚体含量的关系。方法　用N6A血流变仪和标准摆动式旋转 CAST法对 43例脑栓塞患者和 5 1例健康人进行血液流变学及体外模拟血栓的试验 ,并用胶乳定性法及定量法测定 D-二聚体含量。结果　患者血液流变学显著高于健康人、模拟血栓湿重和指数 Q值与健康人有显著差异 ( P<0 .0 5 ) ,血栓长度改变不明显 ( P>0 .0 5 ) ;血浆 D-二聚体含量水平与年龄有关 ,年龄小于 40 y组与大于 40 y组的差异有非常显著性 ( P<0 .0 1 )。结论　对脑栓塞病人进行血液流变学及体外模拟血栓检查和血浆Objective To investigate the relation between the hemorrheological,thrombosis and the blood D-dimer level of the patients with cerebral embolism in vitro.Methods The imitating thrombosis-test(ITT) was performed using the standard method of CAST in 43 adults with cerebral embolism group and 51 healthy adults and the blood D-dimer in the different groups was also compared by the method of latex test.Results The weigh of imitating thrombosis and thrombus index Q in cerebral embolism group was higher than that of control group (P<0.05),but no prominent difference of the length of thrombus between two groups was shown (P>0.05).The blood D-dimer level was closely related to the age with the fact that D-dimer level in patients over 40 years old was much higher than those under 40 years old.Conclusion The ITT and blood D-dimer level are useful in assessing the risk of thrombus formation in vivo and in conducting the prevention and clinical treatment of cerebral embolism.

关 键 词：血液流变学 脑栓塞 体外模拟血栓试验 血栓指数Q D一二聚体 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R446.112[医药卫生—临床医学]