拟黑多刺蚁醇提取物对荷瘤鼠免疫功能的影响  

Effect of alcohol extract of plyrhachis vicina rogher on immune function in mice with tumor

作　　者：陈静[1] 刘巨森[2] 范存欣[1] 吴凤兰[1] 张明珠[1] 李坦[3] 朱建强[3] 孙维琦[3] 

机构地区：[1]广州暨南大学医学院营养学教研室,广东广州510632 [2]广州暨南大学医学院医学信息学教研室,广东广州510632 [3]北华大学医学院,吉林吉林132001

出　　处：《吉林大学学报（医学版）》2004年第4期543-545,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省卫生厅科学基金资助课题 (996 92 )

摘　　要：目的 :研究拟黑多刺蚁 (PVR)醇提取物对荷瘤鼠免疫功能的影响 ,从免疫学角度探讨其抑瘤机理。方法 :随机将小鼠分为对照组 ,PVR醇提液高、中、低实验组。各组小鼠腋下接种 S1 80 小鼠腹水肉瘤细胞 ,建立肿瘤动物模型。对照组用蒸馏水灌胃 ,实验组分别以 0 .5、 1.0和 1.5 g· kg- 1 PVR醇提液灌胃 ,连续 10 d,以肿瘤重量、抑瘤率 ,脾脏指数 ,白细胞介素 2 (IL- 2 ) ,NK和 L AK细胞活性及 T、B淋巴细胞增殖为评价指标。结果 :PVR明显抑制荷瘤鼠肿瘤细胞的生长 ,促进脾细胞增殖反应和 IL- 2分泌 ,增强 L AK和 NK细胞的活性。结论 :PVR体内抑瘤作用与其增强机体抗肿瘤免疫功能有关。Objective To study the effect of plyrhachis vicina rogher (PVR) on immune function in mice with tumor and the mechanism of tumor inhibition.Methods The BALB/c mice were randomly divided into normal control (NC) group and experimental groups including high, middle and low doses of alcohol extract of PVR. The mice were inoculated with S 180 cell of ascites sarcoma in mice. The tumor model of animal was established. NC group was fed on distillative water. Experimental groups were fed on 0.5,1.0, and 1.5 g·kg -1 alcohol extract of PVR for 10 days. The tumor weight,inhibitory rate of tumor,indexes of spleen, IL-2,activities of tumor killer LAK and NK,proliferation of T,B lymphocytes were used as evaluated indexes.Results Spleen weight, killer activities of the LAK and NK, proliferous reaction of the spleen cell and the level of IL-2 secretion in mice treated with alcohol extract of PVR were significantly higher than those in NC group.Conclusion PVR may promote specific and nonspecific immune function of organism and inhibit tumor cells indirectly.

关 键 词：拟黑多刺蚁 免疫 细胞 疾病模型 动物 

分 类 号：R154.1[医药卫生—营养与食品卫生学] R-332[医药卫生—公共卫生与预防医学]