4-[对-(1-苯丙三氮唑)甲基]苯丙烯酸钠抗实验性心律失常的作用  

Effect of P-(1-Benzotriazole methl)-Benylacrylic acid sodium on experimental arrhythmias

作　　者：张红英[1] 李丽波[2] 李迎军[1] 朴日龙[1] 秦孝智[3] 

机构地区：[1]延边大学医学院机能学中心实验室,吉林延吉133000 [2]延边大学药理学教研室,吉林延吉133000 [3]延边大学附属医院心内科,吉林延吉133000

出　　处：《中国药理学通报》2004年第7期815-817,共3页Chinese Pharmacological Bulletin

基　　金：吉林科委科研基金资助项目;No 93 2 90 1 2

摘　　要：目的　研究 4 [对 (1 苯丙三氮唑 )甲基 ]苯丙烯酸钠的抗实验性心律失常作用。方法　采用多种心律失常动物模型观察药物对实验性心律失常的作用。结果　 4 [对 (1 苯丙三氮唑 )甲基 ]苯丙烯酸钠 2 5 ,12 5mg·kg-1iv可明显提高乌头碱诱发大鼠、哇巴因诱发豚鼠室性早博、室性心动过速、室颤及心脏停搏的用量 ;延缓氯化钡诱发大鼠心律失常的出现时间 ,缩短持续时间 ,减少出现双相性心律失常出现的动物数。结论　 4 [对 (1 苯丙三氮唑 )甲基 ]苯丙烯酸钠具有明显的抗心律失常作用。Aim To study the effect of [P-(1-Benzotriazole methl)-Benylacrylic acid sodium,abbreviated for BMBS] on experimental arrhythmias. Methods Arrhythmias models induced by drugs in animals were used to observe the effect of BMBS on experimental arrhythmias. Results BMBS 25,12.5 mg·kg -1 iv markedly increased the dose of aconitine for inducing Ventricular premature beats (VP), ventricular tachycardia (VT) and ventricular fibrillation (VF) in rats, as well as that of ouabain for inducing VP, VT, VF and cardiac arrest (CA) in guinea pigs. Also, it postponed the onset time and shortened the duration of arrhythmias induced by barium chloride in rats and decreased the number of animals showing biphasic arrhythmias. Conclusion BMBS has significant effect on experimental arrhythmias.

关 键 词：4-[对-(1-苯丙三氮唑)甲基]苯丙烯酸钠 心律失常 乌头碱 哇巴因 氯化钡 

分 类 号：R-332[医药卫生]