移植物抗肿瘤效应及其在实体瘤治疗中的意义  

Graft-versus-tumor effect and its significance in the treatment of solid tumor

作　　者：翟光林[1] 姜藻[1] 

机构地区：[1]东南大学临床医学院,江苏南京210009

出　　处：《东南大学学报（医学版）》2004年第4期282-285,共4页Journal of Southeast University(Medical Science Edition)

摘　　要：异基因造血干细胞移植 (Allo HSCT)因具有独特的移植物抗恶性病效应常用来治疗某些恶性血液病 ,近年来Allo HSCT在临床上尝试性地用来治疗某些实体瘤并取得了一定的疗效 ,现就AlloAllogeneic hematopoietic stem cell transplantation(Allo-HSCT) has proved to have a unique immune-mediated antitumor effect in patients with hematologic malignancies. However,recently more investigators have come to recognize that antineoplastic effect mediated by immunopotent donor T-cells transplanted with the stem cell allograft can be induced against solid malignancies and achieved some therapeutic effect.This article reviews the graft-versus-tumor effect and its immunotherapeutic mechanism to investigate the potential of allogeneic immunotherapy for treating solid tumor.

关 键 词：移植物 抗肿瘤效应 实体瘤 治疗 免疫机制 异基因造血干细胞移植 

分 类 号：R730.5[医药卫生—肿瘤]