多巴胺转运体基因与迟发性运动障碍的关联性  

An association study between dopamine transporter gene and tardive dyskinesia in schizophrenic patients

作　　者：龙彬[1] 朱丽萍[1] 张野[1] 江三多[1] 高哲石[1] 

机构地区：[1]上海市精神卫生中心,201108

出　　处：《临床精神医学杂志》2004年第4期203-205,共3页Journal of Clinical Psychiatry

摘　　要：目的 :探讨多巴胺转运体 (DAT1)基因小卫星多态与迟发性运动障碍 (TD)的关联性。　方法 :采用Amp FLP技术 ,对 99例精神分裂症伴TD患者和 12 0名正常人的DAT1基因多态性进行检测 ,比较各组间等位基因和基因型频率分布的差异。　结果 :共观察到 5种等位基因 :32 0bp、36 0bp、4 4 0bp、4 80bp和 5 2 0bp。经吻合度检验 ,TD组和正常对照组DAT1基因各基因型的分布均符合Hardy Weinberg平衡法则。与正常对照组相比较 ,TD组中仅 36 0bp等位基因频率显著减少 (P <0 0 5 )。经关联性分析 ,DAT1基因该多态与TD不相关联。在TD组中 ,基因型频数及等位基因频数与病程、家族史、药物、剂量和异常不自主运动评定量表 (AIMS)评分无显著性意义 (P >0 0 5 )。　结论 :DAT1基因该位点多态可能与TD的发生无关。Objective:To investigate the relationship between the miaoisatellite polymorphism of dopamine transporter gene (DAT1) and tardive dyskinesia (TD). Method:Amp-FLP technique was used to detect the minisatellite polymorphism of DAT1 gene in 99 schizophrenia patients with tardive dyskinesia (TD) and 120 healthy controls.The distributions of genotypes and alleles were tested according to the Hardy-Weinberg law.The differences of DAT1 polymorphism distrbutions between two groups were tested with Z value. Results:Five alleles of the DAT1 gene were detected as following:320 bp,360 bp,440 bp,480 bp and 520 bp.The distributions of genotype and allele met the Hardy-Weinberg law.The distribution of 360bp allele was different significantly between two groups.By association analysis,the polymorphism of DAT1 gene did not associate with TD. Conclusion:May be the polymorphism of DAT1 gene has no effect on TD.

关 键 词：迟发性运动障碍 多巴胺转运体基因 小卫星多态 

分 类 号：R749[医药卫生—神经病学与精神病学]