丁螺环酮对难治性抑郁症治疗的辅助作用  

Comparative study of citalopram combined with buspirone for treatment of refractory depression

作　　者：孙全新[1] 曾德志[1] 罗世芳[1] 郑忠烈[1] 

机构地区：[1]湖北咸宁医学院附属第二医院精神病学研究所,437100

出　　处：《临床精神医学杂志》2004年第4期221-222,共2页Journal of Clinical Psychiatry

摘　　要：目的 :观察西酞普兰合并丁螺环酮对难治性抑郁症的疗效和不良反应。　方法 :对 4 2例难治性抑郁症患者 ,随机分为合用组 (西酞普兰合并丁螺环酮 ,2 2例 )和单用组 (单用西酞普兰 ,2 0例 )治疗 6周。采用汉密尔顿抑郁量表 (HAMD)、汉密尔顿焦虑量表 (HAMA)评定疗效 ,以副反应量表 (TESS)评定不良反应。　结果 :治疗第 1、2、4、6周末两组间HAMD及HAMA评分比较 ,合用组低于单用组 ,差异有显著性 ;治疗 6周末合用组显效率达 72 .7% ,显著高于单用组的 4 0 % ;两组间TESS评分同期比较差异均无显著性。　结论 :西酞普兰合并丁螺环酮对难治性抑郁症的疗效优于单用西酞普兰 ,且起效快 ,不良反应轻微。Objective:To observe the clinical efficacy and side effects of citalopram combined with buspirone for treating refractory depression. Method:Forty-two patients with refractory depression were randomly assigned to study group (citalopram combined with buspirone,n=22)and control group (single citalopram,n=20) for 6 weeks.Effects and side reactions were evaluated with Hamilton depression scale(HAMA),Hamilton anxiety scale(HAMD) and the treatment emergent symptoms scale (TESS) before and after the treatment. Results:HAMD and HAMA scores of the study group were significantly lower than those of the control group at the end of the 1,2,4 and 6 weeks treatment.The significant improvement rate was remarkably higher in the study group(72.7%)than in the control group (40%).No significant difference of TESS scores was found between two groups. Conclusion:Citalopram combined with buspirone to treat refractory depression has better efficacy and fewer adverse events,taking effect more quickly.

关 键 词：抑郁症 西酞普兰 丁螺环酮 

分 类 号：R749.4[医药卫生—神经病学与精神病学]