溶血磷脂酸在缺血性脑血管病早期诊断和治疗中的价值  

Value of lysophosphatidic acid in early diagnosis and treatment of ischemic cerebrovascular disease

作　　者：刘南海[1] 朱祖余[1] 曾繁银[1] 黄晓峰[1] 邱芳[1] 

机构地区：[1]赣南医学院附属医院神经科,江西赣州341000

出　　处：《临床荟萃》2004年第17期979-981,共3页Clinical Focus

摘　　要：目的　探讨溶血磷脂酸在缺血性脑血管病早期诊断和治疗中的临床价值。方法　对 30例脑梗死患者、2 0例短暂性脑缺血发作 [TIA(仅于 3天内发作者为TIA1组 ) ]患者、9例反复TIA发作 (首次TIA发作 3天后仍有发作者为TIA2组 )患者 ,在发病 3天内、2周、4周时定磷法测定血浆溶血磷脂酸 (LPA)水平 ,并与 2 0例健康人作对照。测定 6例反复TIA发作患者抗血小板治疗 3个月 (试验组 )治疗前后血浆LPA水平 ,并与 5例未抗血小板治疗者 (对照组 )作对照。结果　①脑梗死组在发病 3天内、2周时 ,TIA1组发病 3天内及TIA2组发病 3天内、2周、4周时血浆LPA水平升高 ,与健康对照组比较 ,差异有统计学意义 (P <0 .0 1)。②反复TIA发作患者治疗 3个月后试验组血浆LPA水平显著下降 ,与健康对照组比较 ,差异无统计学意义 (P >0 .0 5 ) ,对照组血浆LPA水平下降 ,与健康对照组比较 ,差异有统计学意义 (P <0 .0 1)。结论　LPA可作为早期诊断缺血性脑血管病的一项指标 ;存在脑血管病危险因素患者 ,当血浆LPA水平升高时 ,应积极抗血小板等治疗 ,LPA可作为疗效指标之一。Objective To observe the value of lysophosphatidic acid(LPA) in early diagnosis and treatment of ischemic cerebrovascular disease.Methods The investigation included 30 patients with cerebral infarction,20 patients with transient ischemic attack(TIA),who had an attack within 3 days only(TIA1),9 patients suffered from repeated TIA until after 3 days(TIA2) , and 20 healthy subjects. Within 3 days of onset and at 2 weeks and 4 weeks of onset,the quantity of LPA in above patients and healthy subjects was determined.Six patients suffered from repeated TIA until after 3 days, who were given treatment of antiplatelet for 3 months (test group) and compared with 5 patients (comparison group) who were not given treatment of antiplatelet for 3 months, the quantity of LPA of two groups was determined before and after treatment.Results ①LPA level in group of cerebral infarction within 3 days of onset and at 2 weeks of onset,group of TIA1 within 3 days,group of TIA2 within 3 days of onset and at 2 weeks,4 weeks of onset were significantly higher than that in healthy group (P< 0.01).②LPA level in the test group decreased evidently after treatment of 3 months, differences between test group and healthy subjects were not statistically significant(P> 0.05); LPA level in the comparison group decreased also after treatment of 3 months, but it was significantly higher than that in healthy subjects(P< 0.01).Conclusion LPA may be considered as an index of early diagnosis of ischemic cerebrovascular disease; an active antiplatelet treatment should be given to patients with risk factor of cerebrovascular disease and higher level of LPA, and LPA can be an index of curative effect.

关 键 词：脑血管意外 脑缺血 暂时性 溶血脂素类 

分 类 号：R743.3[医药卫生—神经病学与精神病学]