马来酸替加色罗的两种晶型结构  

Two Crystals of Tegaserod Maleate

作　　者：苏国强[1] 朱崇泉[1] 

机构地区：[1]江苏省药物研究所,南京210009

出　　处：《中国药科大学学报》2004年第4期379-380,共2页Journal of China Pharmaceutical University

摘　　要：AIM:To study the crystals form of tegaserod maleate. METHOD:The DSC,TGA and X -ray powder diffraction were used in this observation. RESULT and CONCLUSION: Twe crystals of tegaserod maleate,S-form and W-form,were obtained and it was confirmed that the S-crystal form is a monohydrate crystal. Preliminary pharmacokinetic test shows that the S-crystal form bioavailability is 46% in mice and the W-crystal form is only 19%.AIM:To study the crystals form of tegaserod maleate. METHOD:The DSC,TGA and X -ray powder diffraction were used in this observation. RESULT and CONCLUSION: Twe crystals of tegaserod maleate,S-form and W-form,were obtained and it was confirmed that the S-crystal form is a monohydrate crystal. Preliminary pharmacokinetic test shows that the S-crystal form bioavailability is 46% in mice and the W-crystal form is only 19%.

关 键 词：马来酸替加色罗 晶型 X-射线粉末衍射 差示扫描量热法 热重分析法 

分 类 号：R914[医药卫生—药物化学]