多抗甲素联合肿痛安治疗复发性口疮的疗效观察  

The effect of polyactin A and/or Zhongtong’an in the treatment of recurrent aphtha ulceraiton

作　　者：胥红[1] 苏葵[2] 刘蜀凡[3] 

机构地区：[1]广东省中山市博爱医院口腔科,528403 [2]广东省中山市人民医院口腔科 [3]中南大学湘雅医院口腔科

出　　处：《实用口腔医学杂志》2004年第4期478-480,共3页Journal of Practical Stomatology

摘　　要：目的 :探讨一种治疗复发性口疮的全身用药方法和免疫制剂治疗的理论基础。方法 :13 5例复发性口疮患者接受多抗甲素、肿痛安治疗 ,观察其治疗效果 ,并于治疗前后采用流式细胞术检测患者外周血T淋巴细胞亚群。结果 :多抗甲素联合肿痛安治疗总有效率达 97.78% ,治疗后CD3‘、CD4‘、CD8、CD4/CD8升高 ,CD8降低 ,差异有显著性。结论 :采用多抗甲素联合肿痛安治疗复发性口疮是一种行之有效的治疗方法 ,其机制是提高了患者的细胞免疫功能。Objective: To study the effects of polyactin A or Zhongtong’an or the combination of both in the treatment of recurrent aphtha ulceration(RAU). Methods:135 cases of RAU were randomly devided into 3 groups. In group 1, 44 cases were given polyactin A at 10 mg 3 times/d; in group 2, 46 cases were given Zhongtong’an at 0.56 g 3 times/d; in group 3, 45 cases were treated by the combination of both. The treatment was countinued for 8 weeks and the patients were followed-up for 1 year. T lymphocyte subgroup was examined by the detection of expression of CD 3,CD 4,CD 8 and CD 4/CD 8. Results: The effectiveness ration (%) in group 1, 2 and 3 was 69.57, 50.00 and 97.70 respectively (1 vs 2, P>0.05;1 or 2 vs 3,P<0.01). In group 1 and 2, CD 3, CD 4 and CD 4/CD 8 expression did not change singnificantly after treatment; while in group 3 CD 3,CD 4 and CD 4/ CD 8 increased(P<0.05), CD 8 decreased(P<0.05).Conclusion:The combination of polyactin A and Zhongtong’an may be effective in the treatment of RAU.

关 键 词：口疮 T淋巴细胞亚群 治疗 疗效观察 多抗甲素 肿痛安 

分 类 号：R781.5[医药卫生—口腔医学]