非梗阻性无精子症相关病因分析  

Analysis of the Relative Etiology of Non-obstructive Azoospermia

作　　者：段玲[1] 尔西丁.买买提 赵金萍[1] 段磊 刘琴 刘瑞军 王成军 杜红[1] 

机构地区：[1]新疆医科大学第一附属医院妇产科,新疆乌鲁木齐830054 [2]新疆医科大学公共卫生学院,新疆乌鲁木齐830054 [3]新疆维吾尔自治区中医院检验科,新疆乌鲁木齐830000 [4]新疆维吾尔自治区计划生育研究所,新疆乌鲁木齐830011

出　　处：《中华男科学杂志》2004年第8期616-618,622,共4页National Journal of Andrology

摘　　要：目的 :探讨非梗阻性无精子症患者血清和精浆中的性激素水平、精浆表皮生长因子、α 葡萄糖苷酶、果糖水平及其变化 ,以及染色体分析的意义。　方法 :采用放射免疫法、比色法、染色体G、C显带等方法 ,对 36例已婚非梗阻性无精子症患者和 2 6例正常已婚有精子男性进行生殖内分泌、遗传学等结果比较 ,探讨导致不育的病因。　结果 :非梗阻性无精子症患者血清中FSH、LH、PRL、E2均高于正常对照男性 ,T水平两者间差异无显著性。而精浆中除FSH外 ,其余差异均无显著性。非梗阻性无精子症组性染色体异常 2例 ,大Y 2例 ,小Y 7例 ,精浆表皮生长因子、果糖两者间无相关性。　结论 :非梗阻性无精子症与血清性激素水平、α 葡萄糖苷酶。Objective: To investigate the levels and changes of sexual hormone in serum and seminal plasma, and the pidermal growth factor(EGF), alpha glucosidase, and fructose in the seminal plasma of non obstructive azoospermic patients, and to assess the significance of the analysis of their chromosomes. Methods: Thirty six non obstructive azoospermic males and 26 normal males were chosen. The results in reproductive endocrine and genetics obtained by radioimmunoassay, colorimetry, and chromosomes G and C banding assay were compared and analyzed to explore into the causes of infertility. Results: The levels of FSH, LH, PRL and E2 in the serum of the non obstructive azoospermic patients were higher than those of the control group, but the T level had no significant difference between the two groups. There were no obvious differences in the sexual hormones except in FSH of the seminal plasma. There were 2 cases of abnormal sex chromosomes, 2 cases of big Y chromosomes and 7 cases of small Y chromosomes in the non obstructive azoospermic patients. No correlation was found between EGF and fructose in the seminal plasma. Conclusion: The level of sexual hormone in serum, alpha glucosidase in seminal plasma and abnormal chromosomes might be closely related to non obstructive azoospermia.

关 键 词：非梗阻性无精子症 性激素 染色体 表皮生长因子 Α-葡萄糖苷酶 果糖 

分 类 号：R698.2[医药卫生—泌尿科学]