短暂性脑缺血发作患者的认知功能及脑血流改变  

Change of cognitive function and cerebral blood flow in patients with transient ischemic attack

作　　者：解新荣[1] 曹莹[1] 郝舒亮[2] 刘建军[3] 郭新[1] 张祖民[1] 王易娟[1] 

机构地区：[1]兰州军区乌鲁木齐总医院老年病科,830000 [2]兰州军区乌鲁木齐总医院神经电生理室,830000 [3]兰州军区乌鲁木齐总医院核磁共振室,830000

出　　处：《临床神经病学杂志》2004年第4期258-260,共3页Journal of Clinical Neurology

摘　　要：目的　探讨短暂性脑缺血发作 (TIA)患者的认知功能与脑血流改变及两者之间的关系。方法应用事件相关电位 (ERP)、老年认知功能量表 (SECF)、磁共振血管成像 (MRA) ,对 35例TIA患者进行检测评估 ,并将ERP及SECF检测结果与性别、年龄、利手和文化程度方面严格匹配的 33名健康对照者进行对比。结果　与对照组相比 ,TIA患者的P3 潜伏期明显延长 (P <0 0 5 ) ;有明显的记忆障碍 ,注意力、注意集中能力、信息提取能力均下降 ;TIA组 94 2 8%有脑动脉狭窄和闭塞。结论　TIA患者有多项认知功能障碍 ,尤以记忆损害突出 ;有持久的脑血流低灌注 。Objective To investigate the change of cognitive function and cerebral blood flow in patients with transient ischemic attack(TIA).Methods 35 patients with TIA and 33 normal controls who matched in sex, age, right handed and education were tested by events related potential(ERP), the scale of elderly cognitive function(SECF) and magnetic resonance angiography(MRA).Results The peak latencies of P 3 components of ERP in the patients were significantly delayed as compared with the control group( P<0.05). There was significant impairment of memory, attention/concentration and capability of acquiring information in the patient group. 94 percent of the patients had stenosis or obstruct in the cerebral arteries.Conclusion Patients with TIA have various impairments of cognitive function especially in memory;hare cerebral blood flow decreased last hypoperfusion is related to these cognitive impairments.

关 键 词：短暂性脑缺血发作 认知功能 磁共振血管成像 脑血流 老年认知功能量表 事件相关电位 

分 类 号：R743.3[医药卫生—神经病学与精神病学]