一步合成侧链含活性羧基的聚(酯-碳酸酯)  

One-Step Synthesis of Poly(Ester-Carbonates) Containing Pendant Carboxylic Groups

作　　者：贺枫[1] 梁芸[1] 冯俊[1] 程峰[1] 卓仁禧[1] 

机构地区：[1]武汉大学生物医用高分子材料教育部重点实验室,湖北武汉430072

出　　处：《武汉大学学报（理学版）》2004年第4期453-457,共5页Journal of Wuhan University:Natural Science Edition

基　　金：国家自然科学基金(20104005);武汉市青年科技晨光计划(20015005041)资助项目

摘　　要：报道了多孔硅球固定化猪胰脂肪酶(IE)催化一步合成侧链含活性羧基的聚(酯 碳酸酯)的方法.所得共聚物经红外光谱(IR)、核磁共振氢谱(1HNMR)和特性粘度表征.研究了反应温度、反应时间、IE用量及共聚单体5 甲基 5 羧基三亚甲基碳酸酯(MCC)和丙交酯(DLLA)的摩尔投料比n(MCC)/n(DLLA)对共聚反应的影响.结果表明:反应温度150℃,IE用量0.5%,反应时间48h,n(MCC)/n(DLLA)=1∶4为最佳的共聚反应条件.在此条件下,聚合物的粘度和产率分别达到9.86mL·g-1和89.6%.One-step synthesis of poly(ester-carbonates) containing pendant carboxyl groups had been successfully performed using immobilized lipase on porous silica beads as catalysts. The copolymers were characterized by IR,^(1)H NMR and Ubbelohde viscometer. The factors affecting the viscosity of the copolymer and the monomer conversion such as reaction temperature, reaction time, enzyme concentration and the ratio of the two monomers were investigated. The results show that polymerization at 150 ℃, 0.5% of IE concentration, n(MCC)/n(DLLA) =1∶4 and 48 h, gave the highest viscosity of poly(DLLA-co-MCC).

关 键 词：固定化酶 聚乳酸 聚碳酸酯 活性羧基 酶促开环聚合 

分 类 号：O633.14[理学—高分子化学]