四抗感冒口服液的抗病毒、抗菌及镇痛作用研究  

Study on the anti-virus function,anti-bacteria function and analgesic effect of Sikang ganmao oral liquores

作　　者：郑芙林[1] 濮跃晨[2] 吴亦伦 刘家全 赵辉[1] 方丽[1] 张梅芳[1] 

机构地区：[1]安徽理工大学医学院药理学教研室,安徽淮南232001 [2]安徽省立医院检验科,安徽合肥230001 [3]安徽省医学科学研究所,安徽合肥230001 [4]中国基层医药杂志社,安徽淮南232001

出　　处：《中国药理学通报》2004年第8期949-951,共3页Chinese Pharmacological Bulletin

摘　　要：目的　研究四抗感冒口服液 (CCD)的抗病毒、抗菌及镇痛作用。方法　应用病毒致细胞病变作用观察CCD的抗病毒作用 ;应用平皿挖洞灌药法观察CCD的抑菌作用 ;应用热诱发小鼠疼痛反应模型和冰醋酸诱导小鼠扭体反应模型观察CCD对疼痛的抑制作用。结果　CCD对疱疹病毒Ⅰ型的半数有效浓度为 0 98g·L-1。CCD 1 0 0g·ml-1对金葡菌(ATCC 2 5 92 3)、金葡菌 (MRSA)、表皮葡萄球菌、肺炎链球菌和草绿色链球菌均有抑制作用。CCD 5 0g·kg-1和 10 0g·kg-1可明显延长小鼠热痛反应潜伏期 (P <0 0 5 ,P <0 0 1) ,提高小鼠的痛阈值 ,且维持时间较阿司匹林长。CCD 10 0g·kg-1与 2 0 0g·kg-1对小鼠扭体反应次数有明显抑制作用 (P<0 0 1)。结论　CCD具有一定的体外抗病毒、抗菌作用 ;CCD具有镇痛作用 ,且作用维持时间较长。Aim To study the effects of Sikang ganmao oral liquores(CCD) on virus,bacteria and analgesia.Methods Virus induced cell pathological changes were used to observe the anti virus effect of CCD;the method of pouring drug into plate media holes was adopted to observe the anti bacteria effect CCD;and heat induced pain response and acetic acid induced writhing in mice were employed to observe the analgesic effect of CCD.Results The median effective concentration of CCD anti herpes virus Ⅰ was 0.98 g·L -1 .CDD 1 0 g·ml -1 showed inhibition against staphylococcus aureus(ATCC 25923,MRSA),epidermidis staphylococcus,streptococcus pneumoniae and streptococcus viridans CCD 5.0 and 10 0 g·kg -1 prolonged incubation period of hot plate reaction in mice(P<0 05,P<0 01).CCD 10 0 and 20 0 g·kg -1 showed marked suppressive effect on writhing induced by acetic acid in mice(P<0 01).Conclusion CCD has anti virus and bacteria function.It also possesses analgesic effect for a relatively long time.

关 键 词：四抗感冒口服液 抗病毒作用 抗菌作用 镇痛作用 

分 类 号：R-332[医药卫生] R944.1