转化生长因子β1在涎腺肿瘤中的表达及意义  

Significance and expression of transforming growth factor-β1 in human salivary gland tumors

作　　者：黄湛[1] 李国林[1] 李晓刚[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院口腔颌面外科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2004年第4期365-367,共3页Journal of Harbin Medical University

摘　　要：目的　探讨转化生长因子 β1(TGF β1)在涎腺良、恶性肿瘤中的表达及其意义。 方法　应用免疫组化方法研究了 4 0例涎腺良、恶性肿瘤石蜡标本。结果　良性肿瘤和低度恶性肿瘤呈强阳性或阳性表达 ,高度恶性肿瘤呈阴性或弱阳性表达 ,其差异具有显著性 (P <0 .0 1)。结论　TGFObjective To explore the expression and distribution of transforming growth factor-β1(TGF-β1) in human salivary gland tumors.Methods Forty cases of salivary gland tumors were studied using immunohistochemistry methods.Results The over-expression of TGF-β1 were seen in all benign salivary gland tumors and some well-differentiated malignant salivary gland tumors while lightly positive or even negative expression was seen in poorly differentiated ones(P<0.01).Conclusion The expression of TGF-β1 may have some relations to the progression and differentiation of salivary gland tumors.

关 键 词：细胞因子 转化生长因子 涎腺肿瘤 

分 类 号：R739.87[医药卫生—肿瘤]