非小细胞性肺癌患者血清中可溶性白细胞介素-2受体浓度变化的临床意义  

The Clinicopathological Significance of Serum-soluble Interleukin-2 Receptor Concentration Change in Non-small-cell Lung Cancer Patients

作　　者：金光香[1] 段文卓[1] 孙传美[1] 魏萍[1] 

机构地区：[1]潍坊医学院,山东潍坊261042

出　　处：《潍坊医学院学报》2004年第4期253-255,共3页Acta Academiae Medicinae Weifang

摘　　要：目的　探讨非小细胞性肺癌 (NSCLC)患者血清中可溶性白细胞介素 2受体 (sIL 2R)浓度变化的临床病理学意义。方法　应用酶联免疫吸附试验 (ELISA)测定NSCLC患者和健康献血员血清的sIL 2R浓度。结果　早期NSCLC患者血清sIL 2R浓度与对照组相比差异无显著性 (P <0 .0 5 )。晚期NSCLC患者血清sIL 2R浓度明显高于对照组 (P <0 .0 1)。有肺内转移的NSCLC病人血清sIL 2R浓度明显高于无肺内转移的病人 (P <0 .0 1)。血清sIL 2R浓度鉴定肺内转移的敏感性达到 87.5 % ,特异性达到 75 % .结论　NSCLC病人血清中sIL 2R浓度的增高是肺内转移的指征 ,对于NSCLC病人手术选择、临床治疗及预后评价有重要的意义。Objective To evaluate the clinicopathological significance of serum soluble interleukin-2 receptor concentrations in patients with non-small cell lung cancer (NSCLC).Methods Preoperative serum sIL-2R concentrations were determined by enzyme-linked immunosorbent assay (ELISA) in 65 patients with NSCLC and 49 healthy volunteers.Results Serum sIL-2 concentrations were not significantly higher in NSCLC patients than in normal controls(P<0.05),Serum sIL-2 concentrations were significantly higher in patients with stage ⅢB or Ⅳ diseases than in normal controls (P<0.01).The present of intrapulmonary metastasis was the only clinicopathological feature that was significantly correlated to serum sIL-2 concentrations(P<0.01).The sensitivity of serum sIL-2 concentrations in identifying the presence of intrapulmonary metastasis was 87.5%,specificity was 75%.Conclusion Elevated preoperative serum sIL-2R concentrations in patients with NSCLC reflect the occurrence of intrapulmonary metastasis.It is important significance for clinical selecting surgical procedure and assessing the prognosis and scheme of therapy.

关 键 词：可溶性白细胞介素-2受体 肺肿瘤 转移 

分 类 号：R734[医药卫生—肿瘤]