新型1．5T MR对大鼠诱发肝癌进行^1 H-MRS扫描可行性的初步分析  

Feasibility of 1H-MRS in the DEN induced rat hepatocellular carcinoma by a new 1.5T MR scanner

作　　者：赵卫东[1] 管生[1] 彭卫军[2] 周康荣[1] 唐峰[2] 毛建[2] 曹光 

机构地区：[1]复旦大学附属中山医院放射科,上海200032 [2]复旦大学附属肿瘤医院放射科,上海200032 [3]美国GE公司研发部,上海200040

出　　处：《中国癌症杂志》2004年第4期329-332,共4页China Oncology

基　　金：上海市教委科技发展基金项目 (No.0 3JG0 5 0 3 7) ;卫生部重点科研项目 (No .2 0 0 114 2 0 )

摘　　要：目的 :探讨应用新型 1.5T磁共振扫描仪对二乙基亚硝胺 (DEN)诱发大鼠肝癌实施氢质子磁共振波谱(1H MRS)检查的可行性 ,并对该模型不同阶段的波谱曲线变化特征作初步了解。方法 :建立诱发Wistar大鼠肝癌模型 ,分阶段随机抽取动物进行1H MRS检查 ,而后处死动物 ,对其肝脏进行组织学观察。结果 :3只大鼠意外死亡 ,其余 2 7只 (90 % )大鼠均按照计划进行了扫描及病理处置。T1WI图像显示解剖结构较好 ,但在病变细节方面不如T2 WI序列。经过逐步改良扫描方法 ,本组单体素和多体素扫描的成功率分别达到 6 4 %及 5 0 %。结论 :DEN诱导大鼠肝癌模型适合用于影像研究 ,新型 1.5T磁共振扫描机对大鼠肝脏的1H MRS检查是可行的。Purpose:To study the feasibility of 1 H-magnetic resonance spectroscopy ( 1 H-MRS) in the chemical induced rat hepatocellular carcinoma(HCC) model by a new 1.5T MR set and endeavor to have an initial understanding of the characteristics of its cancer development. Methods:Diethylnitrosamine (DEN) induced rat HCC models(n=30) were established. At different intervals rats were randomly scanned before being killed on the following day. Their livers were dissected for histopathologic study. Results:Three rats died unexpectedly. 27 rats (90%) developed liver lesions and were investigated according to the plan. T 1 WI is good for demonstration of anatomic structure and T 2 WI at showing the lesions in detail. The scanning methods have been improved gradually. 1 H-MRS results were satisfactory for 64% of the single-voxel and 50% of the multi-voxel respectively. Conclusions:DEN induced rat HCC model is suitable for the Medical Imaging studies and liver 1 H-MRS scan is practical with this new 1.5T unit.

关 键 词：大鼠肝癌 氢质子磁共振波谱 磁共振成像 

分 类 号：R735.7[医药卫生—肿瘤]