口腔鳞癌中碱性成纤维细胞生长因子和凋亡抑制因子Survivin的关系  

Relationship between bFGF and Survivin in Oral Squamous Cell Carcinoma.

作　　者：卓贤露[1] 宋宇峰[1] 

机构地区：[1]贵阳医学院附属医院耳鼻咽喉科,贵州贵阳550004

出　　处：《口腔医学研究》2004年第4期366-368,共3页Journal of Oral Science Research

基　　金：贵州省第二批跨世纪人才省政府专项基金 -黔科合人专字 ( 2 0 0 0 ) 9813号

摘　　要：目的 :检测口腔鳞癌组织中碱性成纤维细胞生长因子 (basicfibroblastgrowthfactor,bFGF)和Survivin的表达 ,探讨二者在口腔鳞癌中的关系和临床意义。方法 :收集口腔鳞癌标本 4 2例 (其中有淋巴结转移者 14例 )和10例正常口腔粘膜组织 ,用免疫组织化学染色法检测bFGF和Survivin的表达情况。结果 :口腔鳞癌中bFGF表达阳性率为 6 9.0 5 % (2 9/42 ) ,Survivin的表达阳性率为 80 .95 % (34/42 )。二者共同表达率为 6 1.90 % (2 6 /42 ) ,其表达阳性程度呈显著正相关。结论Objective: To detect the role and the clinical significance of bFGF and Survivin in oral squamous cell carcinoma through observing the relationship between the expression of them in oral squamous cell carcinoma. Methods: Expression of bFGF and Survivin in 42 cases of oral squamous cell carcinoma(14 cases with lymph node metastasis) and 10 cases of normal oral mucosa were detected by immunohistochemistry. Results: bFGF was detected in 29(69.05%) cases of oral squamous cell carcinoma while Survivin were detected in 34(80.95%) cases. Co-expression rate of bFGF and Survivin was 61.90%(26/42). The positive expression degree of them were related to each other significantly. Conclusion: bFGF and Survivin may play an important role in the development of oral squamous cell carcinoma together.

关 键 词：BFGF SURVIVIN 口腔鳞状细胞癌 

分 类 号：R739.8[医药卫生—肿瘤]