不同药物对根管治疗期间炎症急性发作防治效果的实验研究  

Effects of Various Intracanal Medication on Endodontic Flare-ups Following Root Canal Instrumentation

作　　者：史洋 李静 

机构地区：[1]郑州市口腔医院口腔内科,郑州450000

出　　处：《口腔医学》2004年第4期227-229,共3页Stomatology

摘　　要：目的　探讨根管治疗期间炎症急性发作发病机制以及红霉素、氢化可的松两种药物对其防治机制。方法　建立大鼠根尖周炎模型 ,根管预备后在根管内分别置入红霉素、氢化可的松两种药物 ,分别在根管预备后 1d、3d、7d后处死大鼠 ,用放射免疫法检测根尖周组织中前列腺素E2 (PGE2 )含量 ,同时观察根尖组织的病理学表现。结果　根管预备后在根管内放置红霉素 ,与对照组相比 ,根尖周组织炎症显著减轻 (P <0 .0 5 ) ,但根尖周组织中PGE2 含量无明显变化 (P >0 .0 5 )。根管内放置氢化可的松 ,与对照组和红霉素组大鼠相比 ,根尖周组织中PGE2 含量降低 (P <0 .0 5 ) ;同时对根尖周组织炎症有抑制作用。结论　根管内放置红霉素、氢化可的松 ,可以抑制根尖周组织炎症 ,根管内置氢化可的松还可以抑制根尖组织中PGE2 的产生。Objective To measure the effects of intracanal medcations on endodontic flare-ups by measuring tissue levels of periapical prostaglandin E 2(PGE 2) after canal instrumentations. Methods This experimental animal model of periapical inflammation was established with SD rats. Erythomycine and hydrocortisone were placed in canal, respectively, after root instrumentation. Rats were killed on the 1 st ,3 rd and 7 th days after operation. The levels of periapical prostaglandin E 2 were measured by radioimmunity method. We also evaluated the levels of periapicalinflammation with various intracanal medcations. Results There was statistically significant difference in inflammation level between erythomycine group and placebo group (P<0.05), and there was no statistically difference in the level of periapical prostaglandin E 2 (P>0.05). There was statistically significant difference between the two groups between hydrocortisone group and placebo group in inflammation level (P>0.05). Conclusion Erythomycine as the intracanal medication could not effectively reduce endodontic pain, but could significantly inhibit the periapical inflammation. Hydrocortisone could reduce postoperative pain by inhibiting periapical prostaglandin E 2 and also effectively inhibit the periapical inflammation.

关 键 词：根管治疗 根尖周炎 前裂腺素E2 大鼠 

分 类 号：R781.05[医药卫生—口腔医学]