肝硬化患者胆囊排空功能的变化及其机制的研究  

Changes of gallbladder emptying and its mechanism in cirrhotics

作　　者：熊良庚[1] 沈鼎明[1] 

机构地区：[1]重庆医科大学附属第二医院消化科,重庆400010

出　　处：《医师进修杂志》2004年第9期22-22,24,共2页Journal of Postgraduates of Medicine

摘　　要：目的　探讨肝硬化患者胆囊排空功能的变化及其机制。方法　B超测定 98例肝硬化患者空腹和脂肪餐后胆囊的容积 ,计算其排空率 ,并检测血浆胆囊收缩素 (CCK)和血管活性肠肽 (VIP)的含量 ,2 5例健康人为对照组。结果　对照组和ChildA、ChildB、ChildC级肝硬化患者脂肪餐后 1h胆囊排空率依次为 (75 .4± 2 .8) %、(6 3.2± 1.7) %、(5 5 .3± 0 .8) %和 (4 1.2± 1.2 ) % ,逐级比较P <0 .0 5 ;肝硬化患者空腹、餐后血浆CCK和VIP的浓度均高于对照组(P <0 .0 5 )。结论　肝硬化患者胆囊排空率明显低于对照组 ,并且肝功损害越重 ,胆囊排空率越低 。Objective To study the changes of the gallbladder emptying and its mechanism in cirrhotics.Methods The gallbladder′s pre- and postprandial volumes in 98 cirrhotics and 25 controls were checked by B-ultrasonic,and their postprandial gallbladder emptying rates (PGER) were calculated respectively and the plasma levels of cholecystokinin(CCK) and vasoactive intestinal peptide(VIP) were measured.Results PGER in controls,patients with Child A,Child B and Child C were(75.4±2.8)%,(63.2±1.7)%,(55.3±0.8)% and(41.2±1.2)% respectively(P<0.05); The pre-and postprandial plasm CCK and VIP were higher than those of controls.Conclusion The PGER in cirrhotics is markedly lower than those of controls.Moreover, the more advanced cirrhotics, the lower the PGER is, Which may be related to the receptor changes of CCK and VIP.

关 键 词：肝硬化 胆囊排空 胆囊收缩素 血管活性肠肽 

分 类 号：R575.2[医药卫生—消化系统]