核因子-κB p65在宫颈癌组织中的表达及意义  

Expression and Significance of Nuclear Factor-kappa B in Cervical Carcinoma

作　　者：张爱萍[1] 高英敏[1] 张煦[2] 

机构地区：[1]兰州医学院第一附属医院妇产科,730000 [2]兰州医学院病理学教研室

出　　处：《肿瘤防治研究》2004年第9期536-537,共2页Cancer Research on Prevention and Treatment

摘　　要：目的　探讨NF κBp6 5蛋白在宫颈鳞癌及宫颈腺癌组织中表达的意义。 方法　采用免疫组织化学方法 ,用NF κBp6 5单克隆抗体检测 6 4例宫颈鳞癌组织 ,6例宫颈腺癌组织 ,11例宫颈上皮内瘤样病变 (CIN)组织 ,16例慢性宫颈炎组织中NF κBp6 5的表达。 结果　NF κBp6 5在宫颈鳞癌和腺癌中的阳性表达明显高于CIN和慢性宫颈炎组织 ,有淋巴转移的癌组织中NF κBp6 5的阳性表达率高于无淋巴转移的癌组织。结论　NF κBp6Objective To investigate the expression of nuclear factor-kappa B(NF-κB) in human cervical squamous carcinoma tissues and cervical adenocarcinoma tissues.Methods Immunohistochemistry method detection was performed with a special anti p65 monoclonal antibody in 64 cases of cervical squamous carcinoma tissues,6 cases of adenocarcinoma tissues,11 case of cervical intracpithelial neoplasia,16 case of cervicitis.Results NF-κB p65 positive expression rate in cervical squamous carcinomas tissues and cervical adenocarcinoma tissues was significantly higher than that in CIN tissues and cervitics. NF-κB p65 positive expression rate in carcinoma was correlated to lymphatic metastasis of the transportation carcinoma.Conclusion NF-κB p65 in cervical carcinoma may play an important role in the development of cervical carcinoma.

关 键 词：核因子-ΚB P65 宫颈鳞癌 宫颈腺癌 

分 类 号：R737.33[医药卫生—肿瘤]