宫颈鳞状细胞癌脆性组氨酸三体FHIT蛋白表达缺失及其意义  

Loss of Fragile Histidine Triad Protein Expression in Cervical Squamous Cell Carcinoma

作　　者：赵坡[1] 侯宁[1] 曹友俊[1] 

机构地区：[1]北京解放军总医院病理科,100853

出　　处：《肿瘤防治研究》2004年第9期538-539,共2页Cancer Research on Prevention and Treatment

摘　　要：目的　探讨宫颈鳞状细胞癌中FHIT蛋白表达与临床病理的关系。方法　采用FHIT蛋白抗体和免疫组化SP法检测 10 0例宫颈鳞状细胞癌、83例癌旁不典型增生组织和 10例正常宫颈组织中FHIT表达并分析其与组织学分级和临床分期的关系。结果　FHIT蛋白表达的规律为从正常→癌旁→鳞癌 ,其表达逐渐减低。癌组织与癌旁及正常组织比较 ,差异均非常显著 (P =0 .0 0 0 )。FHIT蛋白表达也随鳞癌组织学分级及临床分期增高而明显减低 (P均 =0 .0 0 1)。结论　FHIT表达状况可能与宫颈鳞状细胞癌的发生。Objective To investigate the expression of fragile histidine triad gene protein, FHIT and the possible relationship between FHIT expression and clinicopathological indices in cervical squamous cell carcinoma.Methods Detecting FHIT protein expression in 100 cervical squamous cell carcinomas, 83 para-neoplastic tissues and 10 normal cervical tissues and analysing its relationship to histological grade and clinical stage by SP immunohistochemical method.Results There was a significant difference in FHIT expression between carcinomas and para-neoplastic atypical hyperplastic tissues or normal cervical squamous epithelia (P=(0.000)). Carcinomas with decreased expression of FHIT were corresponding to histological grade (P=(0.001)) and clinical stage (P=(0.001)).Conclusion The decreased expression of FHIT may be associated with the carcinogenesis, decreasing differentiation and invasive behavior of cervical squamous cell carcinoma. It is suggested that the loss of FHIT expression plays an important role in the development and progression of the tumor, and thus may become a new adjunct diagnostic and prognostic marker in cervical squamous cell carcinoma.

关 键 词：宫颈癌 FHIT 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]