弹力蛋白酶诱发犬分叉部囊状动脉瘤模型的研究  

Research on elastase-introduced canine bifurcation saccular aneurysm model

作　　者：王启弘[1] 马廉亭[2] 周志红[1] 张小军[2] 张振海[2] 张新元[2] 束枫[2] 

机构地区：[1]哈尔滨医科大学第二附属医院神经外科,黑龙江哈尔滨150086 [2]中国人民解放军广州军区武汉总医院神经外科,湖北武汉430070

出　　处：《中国微侵袭神经外科杂志》2004年第9期405-408,共4页Chinese Journal of Minimally Invasive Neurosurgery

摘　　要：目的建立犬分叉部囊状动脉瘤模型并研究其形成原因。方法将犬分为3组,将ElastaseⅠ型弹力蛋白酶注入右侧颈总动脉内和(或)结扎右侧颈总动脉,建立分叉部囊状动脉瘤模型,研究动脉瘤的形成过程,1个月内对动脉瘤模型进行复查,并行病理学检查。结果病理和血管造影证实:经酶处理+结扎右侧颈动脉的成瘤率100%,没有结扎而经酶处理过的动脉段没有形成动脉瘤模型,在1个月内弹力板结构有破坏。而单纯结扎动脉组成瘤率为42.8%。结论弹力酶诱发犬分叉部囊状动脉瘤模型重复性好,模型稳定,血流动力学改变是其形成的主要原因,动脉瘤具有良好的形态和病理特征,是比较理想的动脉瘤模型。Objective To establish canine bifurcation saccular aneurysm models and study the causes of formation. Methods Canines were divided into 3 groups, and the ElastaseⅠwas injected into the right common carotid artery combined with of without ligating the artery to establish bifurcation saccular aneurysm models. The causes of formation were studied. The aneurysms were re-examined as well as the pathology was examined in one month. Result Pathology and angiography confirmed that the rate of aneurysm formation in the group dealt with elastase- introduce accompanied with ligating the common carotid artery was 100%, and there was no aneurysm formation despite the elasticity board destruction in the group dealt only with elastase-introduced. The aneurysm formation rate of ligating group was 42.8%. Conclusion Elastase-introduced canine bifurcation saccular aneurysm model can be created repeatedly and stably. The change of homodynamic is the main reason of the formation of aneurysm, and this kind of aneurysm model with the appropriate shape and pathological characteristics is an ideal aneurysm model.

关 键 词：弹力蛋白酶 犬 颈总动脉 动脉瘤模型 发病机理 

分 类 号：R739.4[医药卫生—肿瘤]