食管癌微卫星DNA不稳定性及其与临床病理的关系研究  

Study of the instability of microsatellite DNA and its relationship with clinical pathological parameters in esophageal cancer

作　　者：颜坤[1] 王明荣[1] 房殿春[2] 杨康[1] 

机构地区：[1]第三军医大学西南医院胸心外科,重庆400038 [2]第三军医大学西南医院全军消化内科中心,重庆400038

出　　处：《第三军医大学学报》2004年第17期1570-1572,共3页Journal of Third Military Medical University

摘　　要：目的　检测食管癌中MSI的状况并探讨其与食管癌临床病理特征之间的关系。方法　应用PCR单链构象多态性 (PCR SSCP)技术检测微卫星DNA不稳定性。结果　 45例食管癌组织中MSI有 10例 ,检出率 2 2 2 2 %;MSI与临床分期、病理分级、淋巴结转移、浸润深度等无显著性差异。结论　MSI可能是食管癌发生过程中的早期分子事件 。Objective To detect the state of microsatellite instability (MSI) and investigate the relationship between MSI and clinical pathological parameters in esophageal cancer. Methods MSI was analyzed by PCR SSCP method. Results MSI was detected (22 22%) in 45 cases of esophageal cancer. Effects of MSI on clinical stage, pathological classification, lymph node metastasis, and invasion were not found. Conclusion MSI may be an early molecular pathway and play a certain role in the development of the esophageal cancer.

关 键 词：食管癌 微卫星不稳定性 单链构象多态性 

分 类 号：R394.2[医药卫生—医学遗传学] R735.1[医药卫生—基础医学]