端粒酶活性与子宫内膜癌相关性研究  

A Study on Relationship Between Telomerase Activity and Endometrium Cancer

作　　者：孟君[1] 张凤兰[1] 李佳平[1] 李英勇[1] 

机构地区：[1]广东医学院附属医院妇产科,广东湛江524001

出　　处：《河南肿瘤学杂志》2004年第5期308-309,共2页Henan Journal of Oncology

摘　　要：目的　研究正常子宫内膜组织、不典型增生过长、不同临床分期、组织学分级子宫内膜癌组织中端粒酶活性变化。方法　采用以PCR为基础的端粒酶重复扩增方法及非变性PAGE银染定性法检测不同组织中端粒酶活性。结果　端粒酶活性在子宫内膜癌组织中显著增高 ,在正常子宫内膜组织及不典型增生过长中亦有表达 ,而子宫内膜癌不同临床分期及组织学分级间则无显著差异 (P >0 0 5 )。结论　端粒酶的激活是诱发子宫内膜癌的重要因素 ,但其进展及恶性程度则与肿瘤的进展无显著相关。Objective To study telomerase activity in normal endometrium tissue, atypical hyperplasia, endometrium cancer with different clinical stage, histologic grade.Methods Use PCR based telomerase repeat amplification protocol to test telomerase activity in different tissue. Results Telomerase activity in endometrium cancer is significantly higher than normal tissue (P<0.01). There is telomerase activity in normal and atypical endometrium hyperplasia. No significant difference among different clinical stage and histologic grade.Conclusions Telomerase activity is an important cause to endometrium cancer, but their progress and malignant degree no significant relation with telomere activity.

关 键 词：端粒酶 子宫内膜腺癌 相关性 

分 类 号：R737.33[医药卫生—肿瘤]