糖抗原SLex、Lex、Lea在肺癌中的表达及与病人预后的关系  

Expression of carbohydrate antigens SLex、Lex、Lea in lung cancers andit's relation to prognosis of patients

作　　者：迟英凯[1] 唐建武[2] 王华新[2] 

机构地区：[1]沈阳军区总医院病理科,辽宁沈阳110016 [2]大连医科大学病理学教研室,辽宁大连116027

出　　处：《大连医科大学学报》2004年第3期161-164,共4页Journal of Dalian Medical University

摘　　要：[目的 ]研究Lewis糖抗原在肺癌及其淋巴结转移灶的表达与作用。 [方法 ]免疫组化LSAB法检测SLex、Lex、Lea在肺癌组织中的表达。 [结果 ]在 70例非小细胞肺癌原发灶中 ,SLex、Lex、Lea的阳性率分别为 72 .9% (5 1 /70 )、5 4.3% (38/70 )和 4 4.3% (31 /70 ) ,其淋巴结转移灶中 ,阳性率分别为 6 7.1 % (4 7/70 )、4 7.1 % (33/70 )和 4 0 % (2 8/70 ) ;原发灶与转移灶SLex表达具有显著相关性。 3种Lewis糖抗原在 8例小细胞肺癌均无表达。鳞癌与腺癌低分化型Slex阳性率为 85 .7%(1 2 /1 4 )与 92 .3% (1 2 /1 3) ,分别高于高分化者的 6 0 % (9/1 5 )与 6 5 % (1 3/2 0 ) ;晚期病例高于早期病例。发生转移、复发或死亡的病例 ,SLex表达高于未发生者。 [结论 ]Lewis抗原表达可能与肿瘤细胞组织来源和 /或分化有关 ;Objective] To investigate the relationship of expression of Lewis antigens in primary pulmonary carcinoma to lymph node metastasis. [Method] The expressions of SLex、Lex、Lea of lung cancer were detected by immunohistochemical technique in 70 cases of none small cell lung cancers(NSCLC). [Results] Expression rates of SLex、Lex and Lea in primary lesions were 72.9%(51/70)、54.3%(38/70)and 44.3%(31/70) respectively,and the metastasis lymph node lesions were 67.1%(47/70)、47.1%(33/70) and 40%(28/70) respectively; The expression of SLex in primary ones correlated to those of lymph node metastasis. The expression rates of SLex in poorly differentiated squamous cell carcinoma (85.7% ,12/14) and adeno-carcinoma (92.3%,12/13) were higher than those in well differentiated ones, separately 60% (9/15) and 65% (13/20). The expression rate of SLex in lung cancer with stage II was higher than that with stage I. The expression rate of SLex was higher than those of Lex and Lea. The expression rate of SLex in patients with bad prognosis was higher than that without. [Conclusion] The expressions of Lewis antigens correlate to the origin and differentiation, and infiltration and metastasis in NSCLC.

关 键 词：黏附分子 SLEX LEX LEA 肺癌 转移 

分 类 号：R734.2[医药卫生—肿瘤]