上皮钙黏附素 粘着斑激酶在大肠癌的关系  

Expressoin of E-cadherin and FAK in Colorectal Carcinoma

作　　者：王万里[1] 李怀斌[1] 王刚成[1] 魏莉[1] 

机构地区：[1]河南省人民医院消化内科,郑州市450003

出　　处：《医药论坛杂志》2004年第10期36-37,共2页Journal of Medical Forum

摘　　要：目的　探讨上皮钙黏附素和粘着斑激酶在大肠癌发生、发展中的作用。方法　采用免疫组织化学方法检测了 12例正常大肠黏膜 ,2 8例大肠腺瘤及 4 9例大肠癌组织的E -cad .和FAK表达情况。结果　大肠癌E -cad .膜表达缺失率显著高于正常大肠黏膜和大肠腺瘤 (P <0 .0 1)。大肠癌FAK胞浆阳性率显著高于大肠腺瘤和正常大肠黏膜 (P <0 .0 1)。E -cad .膜表达缺失、FAK表达与大肠癌的浸润程度、淋巴结转移和Dukes分期等因素有关。结论　E -cad .膜表达缺失、FAK表达可能与大肠癌的侵袭和转移有关。Objective To investigate the role of E-cadherin and FAK in the carcinogenesis and progression of colorectal carcinoma.Methods Expression of FAK and E-cadherin was examined immunohistochemically in 12 cases of normal colorectal mucosa, 28 cases of colorectal adenoma, 49 cases of colorectal carcinoma.Results The rate of the reduced membranous expression of E-cadherin in colorectal carcinoma was significantly higher than that in the colorectal adenoma and normal colorectal epithelium(P<001). The rate of FAK expression in colorectal carcinoma was significantly higher than that in the colorectal adenoma and the normal colorectal epithelium (P<0.01) .FAK expression and the reduced membranous expression of E-cadherin was associated with degree of soakage,lymph node metastasis and Dukes stage.Conclusion The reduced membranous expression of E-cadherin and FAK expression might be related to the invasion and metastasis of colorectal carcinoma.

关 键 词：上皮钙黏附素 粘着斑激酶 大肠癌 免疫组织化学 检测 

分 类 号：R735.34[医药卫生—肿瘤]