胞磷胆碱治疗脑出血临床评价  

Clinical Observation on Effect of Cytosine Dihosphate-choline Injection in Treating Patients with Intercerebral Hemorrhage

作　　者：喻芳芳[1] 欧阳存[1] 沈利亚[1] 张晓琴[2] 

机构地区：[1]武汉市第六医院,武汉430015 [2]武汉大学医学院

出　　处：《药物流行病学杂志》2004年第4期178-180,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的 :评价胞磷胆碱在脑出血急性期的治疗作用。方法 :收治脑出血患者 10 1例 ,分成对照组及胞磷胆碱治疗组。记录发病 2 4h内CT测定的血肿出血量、NIHSS评分、SAPSⅡ评分 ,及入院 30d的NIHSS评分及生存状态。进行 χ2 和t检验。结果 :两组患者 2 4h内的CT血肿量、NIHSS评分、SAPSⅡ评分差异不明显 ,表明两组患者病情严重程度差异不明显。但治疗 30d后 ,两组患者的NIHSS评分均较入院时有明显改善 ,胞磷胆碱治疗组改善更明显 ,与对照组比较 ,P <0 .0 5。两组患者的死亡率差异不明显。结论 :胞磷胆碱在脑出血急性期应用不仅不增加死亡率 ,而且能改善神经功能预后 。Objective: To assect the therapeutic effect of cytosine dihosphate-choline(CDP-C) injection in intercerebral hemorrhage(ICH).Method: One hundred and one cases with ICH were divided into two groups(CDP-C group and placebo group). The hemorrhageic volume calculated by CT、NIHSS score、SAPSⅡ score with in 24 hours after symptom onset are recorded. The NIHSS score、the survival and mortality with in 30 day were compared between two groups.Result: There are no significant difference between two groups on the hemorrhageic volume calculated by CT、NIHSS score、SAPSⅡscore with in 24 hours after stroke. After 30 days, the NIHSS score in both of two groups became better, but the CDP-C group much more better than the placebo (P<)0.05)).There is also no significant difference of on mortality between two groups.Conclusion: CDP-C injection could significantly improved not only the functional outcome, but also not increasing the mortality. It is safety and effecty.

关 键 词：胞磷胆碱 脑出血 神经功能预后 

分 类 号：R743.34[医药卫生—神经病学与精神病学]