Empirical antibiotic treatment with piperacillin-tazobactam in Patients with microbiologically-documented biliary tract infections  

作　　者：Gabrio Bassotti Fabio Chistolini Francis Sietchiping-Nzepa Giuseppe de Roberto Antonio Morelli 

机构地区：[1]Gastrointestinal and Hepatology Section,Department of Clinical and Experimental Medicine,University of Perugia,Italy

出　　处：《World Journal of Gastroenterology》2004年第15期2281-2283,共3页世界胃肠病学杂志（英文版）

摘　　要：AIM: To report our experience with empiric antimicrobial monotherapy (piperacillin/tazobactam, of which no data are available in such specific circumstances) in microbiologically-documented infections in patients with benign and malignant conditions of the biliary tract.METHODS: Twenty-three patients, 10 with benign and 13 with malignant conditions affecting the biliary tree and microbiologically-documented infections were recruited and the efficacy of empirical antibiotic therapy was assessed.RESULTS: The two groups featured similar demographic and clinical data. Overall, the infective episodes were most due to Gram negative agents, more than 60% of such episodes (mostly in malignant conditions) were preceded by invasive instrumental maneuvers. Empirical antibiotic therapy with a single agent (piperacillin/tazobactam) was effective in more than 80% of cases. No deaths were reported following infections. CONCLUSION: An empiric therapeutic approach with piperacillin/tazobactam is highly effective in biliary tract infections due to benign or malignant conditions.AIM:To report our experience with empiric antimicrobial monotherapy(piperacillin/tazobactam,of which no data are available in such specific circumstances)in microbiologically-documented infections in patients with benign and malignant conditions of the biliary tract. METHODS:Twenty-three patients,10 with benign and 13 with malignant conditions affecting the biliary tree and microbiologically-documented infections were recruited and the efficacy of empirical antibiotic therapy was assessed. RESULTS:The two groups featured similar demographic and clinical data.Overall,the infective episodes were most due to Gram negative agents,more than 60% of such episodes(mostly in malignant conditions)were preceded by invasive instrumental maneuvers.Empirical antibiotic therapy with a single agent(piperacillin/tazobactam)was effective in more than 80% of cases.No deaths were reported following infections. CONCLUSION:An empiric therapeutic approach with piperacillin/tazobactam is highly effective in biliary tract infections due to benign or malignant conditions.

关 键 词：ADULT Aged Aged  80 and over Anti-Bacterial Agents Biliary Tract Diseases Biliary Tract Neoplasms Drug Combinations Empirical Research FEMALE Humans Infection MALE Middle Aged Penicillanic Acid derivatives PIPERACILLIN 

分 类 号：R575.6[医药卫生—消化系统]