红细胞电泳与血清抗脑抗体联合检测辅助诊断Alzheimer病  

The combination of erythrocyte electrophoresis and serum anti-brain autoantibody assay for diagnosis of Alzheimer disease

作　　者：张京立[1] 陶国枢[1] 尚立新[1] 马向晨[1] 韩志涛[1] 房征宇[1] 张红红[1] 王鲁宁[1] 

机构地区：[1]中国人民解放军总医院老年医学研究所,北京100853

出　　处：《临床检验杂志》2004年第4期284-285,共2页Chinese Journal of Clinical Laboratory Science

基　　金：国家计委攻关项目基金资助课题 ( 85 72 2 3 5 0 2 )

摘　　要：目的　探索经血液临床辅助诊断Alzheimer病 (AD)的可行方法。方法　将病人分AD病组 (11例 )、血管性痴呆组 (13例 )和老年对照组 (5 3例 )共 3组。分别同时进行红细胞电泳和血清抗脑抗体检测。两种方法均为阳性者方视为阳性 ,观察各组诊断总阳性率。结果　AD病组、血管性痴呆组和老年对照组两法合用的阳性率分别为 :36 .4 % (P <0 .0 1)、15 .4 %和 1.9%。结论　红细胞电泳法和血清抗脑抗体联合检测辅助诊断Alzheimer病是可行的。Objective To research a reliable hemo-experimental method to diagnose Alzheimer disease.Methods The patients were divided into three groups.Alzheimer group consisted of 11 cases (67-82 years old,7 males and 4 females).The multiple infarct dementia (MID) group consisted of 13 cases (62-80 years old,8 males and 5 females).The old control group consisted of 53 cases (60-79 years old,25 males and 28 females).Both the erythrocyte electrophoresis assay and the serum anti-brain autoantibody assay were used.Alzheimer disease was diagnosed positively only when the both assays were positive in one patient.Results The positive rates of Alzheimer group,MID group and the old control group were 36.36% (P<0.01),15.38% and 1.89% respectively.Conclusion It is suggested that the combined application of the erythrocyte electrophoresis assay and the serum anti-brain autoantibody assay is a good method for diagnosis of Alzheimer disease.

关 键 词：红细胞电泳 血清抗脑抗体 联合检测 辅助诊断 ALZHEIMER病 

分 类 号：R749.16[医药卫生—神经病学与精神病学]