灯盏花注射液对反复缺血再灌脑损伤小鼠学习记忆功能的影响  

Effect of Erigeron breviscapus Hand-Mazz on learning and memory dysfunction in mice with cerebral ischemia/reperfusion injury

作　　者：田国庆[1] 卢贺起[2] 郭赛珊[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院中医科,北京市100730 [2]中国中医研究院基础理论研究所,北京市100700

出　　处：《中国康复理论与实践》2004年第7期404-405,共2页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的观察灯盏花注射液对反复缺血再灌脑损伤小鼠学习记忆功能的影响。方法 40只小鼠随机分为 :正常对照组、假手术组、模型组、灯盏花组 ,每组 10只。采用双侧颈总动脉夹闭反复缺血再灌术 ,建立脑缺血学习记忆障碍小鼠模型。手术前后各 7d ,灯盏花组腹腔注射灯盏花注射液 0 15ml/d ,其余各组腹腔注射生理盐水 0 15ml/d。以Morris水迷宫测试小鼠学习记忆功能。结果模型组小鼠潜伏期较正常对照组及假手术组延长 (P <0 0 5 )。灯盏花注射液组小鼠潜伏期缩短 ,与模型组比较 ,P <0 0 5。结论灯盏花注射液能改善反复缺血再灌脑损伤小鼠的学习记忆功能。Objective To investigate the effects of Erigeron breviscapus Hand Mazz(EBH) on learning and memory dysfunction in mice with cerebral ischemia/reperfusion injury.Methods 40 mice were randomly divided into control group, sham operated group, model group and EBH group, with 10 mice each. Mice model of cerebral ischemia/reperfusion injury was established by bilateral common carotid artery blocking. 7 days before and after operation, the mice in EBH group were injected i.p. with EBH injection 0 15 ml/d, while those in other groups were injected i.p. with saline 0 15 ml/d. The learning and memory function was tested by Morris water maze.Results The latent period in the model group was longer than that in the normal group and the sham operated group ( P <0 05). EBH could shorten the latent period significantly as compared with those in the model group ( P <0 05). Conclusion EBH can improve learning and memory function in cerebral ischemia/reperfusion injured mice.

关 键 词：灯盏花注射液 学习记忆 缺血再灌注 小鼠 

分 类 号：R743[医药卫生—神经病学与精神病学]